Vaishali Purohit, Jasmine Dwyer, Andrea Moreira, Jenna Li, Emil Fernando, Janette Gomez, Jennifer Saldanha, Thomas Julian, Suzanne Coopey
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Patients with breast weights > 600 g (the extreme NSM group) were compared to patients with breast weights of 600 g or less (the average-volume NSM group).</p>\n <p><b>Results:</b> A total of 184 patients underwent NSM with immediate reconstruction. Forty-three of 184 (23.37%) NSM patients had breast weights > 600 g. Of these, 30 patients had bilateral NSM, for a total of 73 breasts with volumes over 600 g, ranging from 603 to 1658 g. There were significantly more total complications in the extreme NSM compared to average-volume NSM groups (41.86% vs. 21.99%, <i>p</i> = 0.009852). When broken down into major and minor complications, the extreme NSM group had significantly more major complications than the average-volume NSM group (27.91% vs. 12.86%, <i>p</i> = 0.01072), but no difference in minor complications (13.95% vs. 9.29%, <i>p</i> = 0.2205). Overall, one (2.33%) patient in the extreme NSM group had a reconstruction failure, compared to three (2.14%) in the average-volume NSM group. Only two of 43 (4.65%) patients in the extreme NSM group lost their nipples due to total or partial nipple necrosis.</p>\n <p><b>Conclusions:</b> NSM with immediate reconstruction was successful in the majority of patients with large-volume breasts. The rate of nipple loss was acceptably low. Women with breast volumes larger than 600 g who are motivated to save their nipples at the time of mastectomy could be offered NSM.</p>\n </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/6974079","citationCount":"0","resultStr":"{\"title\":\"Extreme Nipple-Sparing Mastectomy: Feasibility of Nipple Preservation and Immediate Reconstruction in Breasts Weighing Over 600 Grams in a Cohort of 43 Patients\",\"authors\":\"Vaishali Purohit, Jasmine Dwyer, Andrea Moreira, Jenna Li, Emil Fernando, Janette Gomez, Jennifer Saldanha, Thomas Julian, Suzanne Coopey\",\"doi\":\"10.1155/tbj/6974079\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Background:</b> Limited data exist on complication rates in nipple-sparing mastectomy (NSM) in patients with large-volume breasts. Our aim was to evaluate the early complication rates of NSM with immediate reconstruction in a consecutive cohort of patients with large-volume breasts.</p>\\n <p><b>Methods:</b> After IRB approval, patients treated with prophylactic or therapeutic NSM and immediate reconstruction from January 2020 to June 2022 at our health network were identified. Patients with breast weights > 600 g (the extreme NSM group) were compared to patients with breast weights of 600 g or less (the average-volume NSM group).</p>\\n <p><b>Results:</b> A total of 184 patients underwent NSM with immediate reconstruction. Forty-three of 184 (23.37%) NSM patients had breast weights > 600 g. Of these, 30 patients had bilateral NSM, for a total of 73 breasts with volumes over 600 g, ranging from 603 to 1658 g. There were significantly more total complications in the extreme NSM compared to average-volume NSM groups (41.86% vs. 21.99%, <i>p</i> = 0.009852). When broken down into major and minor complications, the extreme NSM group had significantly more major complications than the average-volume NSM group (27.91% vs. 12.86%, <i>p</i> = 0.01072), but no difference in minor complications (13.95% vs. 9.29%, <i>p</i> = 0.2205). Overall, one (2.33%) patient in the extreme NSM group had a reconstruction failure, compared to three (2.14%) in the average-volume NSM group. Only two of 43 (4.65%) patients in the extreme NSM group lost their nipples due to total or partial nipple necrosis.</p>\\n <p><b>Conclusions:</b> NSM with immediate reconstruction was successful in the majority of patients with large-volume breasts. The rate of nipple loss was acceptably low. 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引用次数: 0
摘要
背景:关于大乳房患者保留乳头乳房切除术(NSM)并发症发生率的数据有限。我们的目的是评估大乳房患者连续队列中NSM立即重建的早期并发症发生率。方法:在IRB批准后,对2020年1月至2022年6月在我们的卫生网络中接受预防性或治疗性NSM治疗并立即重建的患者进行鉴定。乳房体重>;将600 g(极端NSM组)与乳房重量为600 g或更少的患者(平均体积NSM组)进行比较。结果:184例患者行NSM手术并立即重建。184例NSM患者中43例(23.37%)存在乳房体重;600克。其中30例患者为双侧NSM,共73例乳房体积超过600g,从603到1658 g不等。极端NSM组总并发症明显多于平均NSM组(41.86% vs. 21.99%, p = 0.009852)。重度NSM组主要并发症发生率明显高于中度NSM组(27.91% vs. 12.86%, p = 0.01072),轻度并发症发生率无显著差异(13.95% vs. 9.29%, p = 0.2205)。总的来说,极端NSM组有1例(2.33%)患者重建失败,而平均容量NSM组有3例(2.14%)。极端NSM组43例患者中仅有2例(4.65%)因乳头全部或部分坏死而失去乳头。结论:在大多数大乳房患者中,NSM立即重建是成功的。乳头脱落率是可以接受的低。乳房体积大于600克的妇女在乳房切除术时有保留乳头的动机,可以提供NSM。
Extreme Nipple-Sparing Mastectomy: Feasibility of Nipple Preservation and Immediate Reconstruction in Breasts Weighing Over 600 Grams in a Cohort of 43 Patients
Background: Limited data exist on complication rates in nipple-sparing mastectomy (NSM) in patients with large-volume breasts. Our aim was to evaluate the early complication rates of NSM with immediate reconstruction in a consecutive cohort of patients with large-volume breasts.
Methods: After IRB approval, patients treated with prophylactic or therapeutic NSM and immediate reconstruction from January 2020 to June 2022 at our health network were identified. Patients with breast weights > 600 g (the extreme NSM group) were compared to patients with breast weights of 600 g or less (the average-volume NSM group).
Results: A total of 184 patients underwent NSM with immediate reconstruction. Forty-three of 184 (23.37%) NSM patients had breast weights > 600 g. Of these, 30 patients had bilateral NSM, for a total of 73 breasts with volumes over 600 g, ranging from 603 to 1658 g. There were significantly more total complications in the extreme NSM compared to average-volume NSM groups (41.86% vs. 21.99%, p = 0.009852). When broken down into major and minor complications, the extreme NSM group had significantly more major complications than the average-volume NSM group (27.91% vs. 12.86%, p = 0.01072), but no difference in minor complications (13.95% vs. 9.29%, p = 0.2205). Overall, one (2.33%) patient in the extreme NSM group had a reconstruction failure, compared to three (2.14%) in the average-volume NSM group. Only two of 43 (4.65%) patients in the extreme NSM group lost their nipples due to total or partial nipple necrosis.
Conclusions: NSM with immediate reconstruction was successful in the majority of patients with large-volume breasts. The rate of nipple loss was acceptably low. Women with breast volumes larger than 600 g who are motivated to save their nipples at the time of mastectomy could be offered NSM.
期刊介绍:
The Breast Journal is the first comprehensive, multidisciplinary source devoted exclusively to all facets of research, diagnosis, and treatment of breast disease. The Breast Journal encompasses the latest news and technologies from the many medical specialties concerned with breast disease care in order to address the disease within the context of an integrated breast health care. This editorial philosophy recognizes the special social, sexual, and psychological considerations that distinguish cancer, and breast cancer in particular, from other serious diseases. Topics specifically within the scope of The Breast Journal include:
Risk Factors
Prevention
Early Detection
Diagnosis and Therapy
Psychological Issues
Quality of Life
Biology of Breast Cancer.