Cecilia P Damilano, K Ming Chan Hong, Bethany A Glick, Manmohan K Kamboj, Robert P Hoffman
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Robust rank order multivariate regression analysis was used to assess how age, duration of diabetes diagnosis, HbA<sub>1c</sub> at screen, PHQ-9 score, PAID-T screen, and insurance status predicted HbA<sub>1c</sub> at 1, 2, and 3 years after, and the changes in HbA<sub>1c</sub> over time.</p><p><strong>Results: </strong>HbA1c and changes in HbA1c after one year were related to baseline HbA1c. At 2 and 3 years HbA1c was related to the initial HbA<sub>1c</sub> [β: 0.64 (95 % CI 0.53-0.75) and β: 0.47 (95 % CI 0.33-0.61), respectively], and to PHQ9 at screening [β: 0.07 (95 % CI 0.01-0.14) and β: 0.11 (95% CI 0.03-0.18), respectively]. Relationships were also demonstrated between PHQ9 and changes HbA1c after 2 and 3 years [β: 0.07 (95% CI 0.01-0.14) and β: 0.11 (95 % CI 0.03-0.18), respectively]. PAID-T score was not related to future glycemic control or changes in glycemic control at any time. Insurance status (private 1, public 2) also predicted future glycemic control and changes in HbA<sub>1c</sub> at 1, 2, and 3 years too.</p><p><strong>Conclusions: </strong>Higher PHQ9 scores and public insurance predict worsening glycemic control over 3 years in adolescents with T1D while increased diabetes distress does not.</p>","PeriodicalId":50096,"journal":{"name":"Journal of Pediatric Endocrinology & Metabolism","volume":" ","pages":"311-317"},"PeriodicalIF":1.0000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diabetes distress, depression, and future glycemic control among adolescents with type 1 diabetes.\",\"authors\":\"Cecilia P Damilano, K Ming Chan Hong, Bethany A Glick, Manmohan K Kamboj, Robert P Hoffman\",\"doi\":\"10.1515/jpem-2024-0524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Increased diabetes distress and depression in adolescents with type 1 diabetes (T1D) are associated with poor glycemic control but it is not known whether they predict future glycemic control.</p><p><strong>Methods: </strong>Patient Health Questionnaire (PHQ-9) and Problem Areas in Diabetes-Teen version (PAID-T) scores were given to 275 adolescents (age 13-17 years) with T1D. Robust rank order multivariate regression analysis was used to assess how age, duration of diabetes diagnosis, HbA<sub>1c</sub> at screen, PHQ-9 score, PAID-T screen, and insurance status predicted HbA<sub>1c</sub> at 1, 2, and 3 years after, and the changes in HbA<sub>1c</sub> over time.</p><p><strong>Results: </strong>HbA1c and changes in HbA1c after one year were related to baseline HbA1c. At 2 and 3 years HbA1c was related to the initial HbA<sub>1c</sub> [β: 0.64 (95 % CI 0.53-0.75) and β: 0.47 (95 % CI 0.33-0.61), respectively], and to PHQ9 at screening [β: 0.07 (95 % CI 0.01-0.14) and β: 0.11 (95% CI 0.03-0.18), respectively]. Relationships were also demonstrated between PHQ9 and changes HbA1c after 2 and 3 years [β: 0.07 (95% CI 0.01-0.14) and β: 0.11 (95 % CI 0.03-0.18), respectively]. PAID-T score was not related to future glycemic control or changes in glycemic control at any time. Insurance status (private 1, public 2) also predicted future glycemic control and changes in HbA<sub>1c</sub> at 1, 2, and 3 years too.</p><p><strong>Conclusions: </strong>Higher PHQ9 scores and public insurance predict worsening glycemic control over 3 years in adolescents with T1D while increased diabetes distress does not.</p>\",\"PeriodicalId\":50096,\"journal\":{\"name\":\"Journal of Pediatric Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"311-317\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric Endocrinology & Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/jpem-2024-0524\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/28 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/jpem-2024-0524","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/28 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
目的：青少年1型糖尿病（T1D）患者糖尿病焦虑和抑郁的增加与血糖控制不良有关，但尚不清楚它们是否能预测未来的血糖控制。方法：对275例青少年糖尿病患者（13 ~ 17岁）进行患者健康问卷（PHQ-9）和青少年糖尿病问题区（PAID-T）评分。采用稳健的秩序多变量回归分析来评估年龄、糖尿病诊断持续时间、筛查时的HbA1C、PHQ-9评分、pay - t筛查和保险状况如何预测1、2和3年后的HbA1C，以及HbA1C随时间的变化。结果：HbA1c及1年后HbA1c变化与基线HbA1c相关。2年和3年时，HbA1c与初始HbA1c [β: 0.64（95 % CI 0.53-0.75）和β: 0.47(95 % CI 0.33-0.61)]以及筛查时的PHQ9 [β: 0.07（95 % CI 0.01-0.14）和β: 0.11 (95% CI 0.03-0.18)]相关。2年和3年后，PHQ9与HbA1c变化之间也存在相关性[β: 0.07 （95% CI 0.01-0.14）和β: 0.11(95 % CI 0.03-0.18)]。pay - t评分与未来血糖控制或任何时间血糖控制的变化无关。保险状况（私人1、公共2）也可以预测未来1年、2年和3年的血糖控制和HbA1C变化。结论：较高的PHQ9评分和公共保险可预测青少年T1D患者3年内血糖控制恶化，而增加的糖尿病困扰则不能预测。
Diabetes distress, depression, and future glycemic control among adolescents with type 1 diabetes.
Objectives: Increased diabetes distress and depression in adolescents with type 1 diabetes (T1D) are associated with poor glycemic control but it is not known whether they predict future glycemic control.
Methods: Patient Health Questionnaire (PHQ-9) and Problem Areas in Diabetes-Teen version (PAID-T) scores were given to 275 adolescents (age 13-17 years) with T1D. Robust rank order multivariate regression analysis was used to assess how age, duration of diabetes diagnosis, HbA1c at screen, PHQ-9 score, PAID-T screen, and insurance status predicted HbA1c at 1, 2, and 3 years after, and the changes in HbA1c over time.
Results: HbA1c and changes in HbA1c after one year were related to baseline HbA1c. At 2 and 3 years HbA1c was related to the initial HbA1c [β: 0.64 (95 % CI 0.53-0.75) and β: 0.47 (95 % CI 0.33-0.61), respectively], and to PHQ9 at screening [β: 0.07 (95 % CI 0.01-0.14) and β: 0.11 (95% CI 0.03-0.18), respectively]. Relationships were also demonstrated between PHQ9 and changes HbA1c after 2 and 3 years [β: 0.07 (95% CI 0.01-0.14) and β: 0.11 (95 % CI 0.03-0.18), respectively]. PAID-T score was not related to future glycemic control or changes in glycemic control at any time. Insurance status (private 1, public 2) also predicted future glycemic control and changes in HbA1c at 1, 2, and 3 years too.
Conclusions: Higher PHQ9 scores and public insurance predict worsening glycemic control over 3 years in adolescents with T1D while increased diabetes distress does not.
期刊介绍：
The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.
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