性别和性别差异在肺寿命：揭示关键的影响。

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Review Pub Date : 2025-02-19 Print Date: 2025-01-01 DOI:10.1183/16000617.0121-2024

Pasquale Tondo, Claudia Meschi, Marco Mantero, Giulia Scioscia, Matteo Siciliano, Matteo Bradicich, Giulia M Stella

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引用次数: 0

摘要

早在人类生命的胚胎阶段，性别和性别差异就开始显著影响肺实质的发育。虽然这种关联在一些相关肺部疾病的临床表现中是众所周知的，但关于它们在身体发育不同阶段对细胞生物学程序的影响的数据较少。对这些机制的深入了解有助于制定针对完全个性化呼吸医学方法的预防策略。从这个角度来看，本综述旨在分析从胚胎和新生儿阶段到青春期、成年期和老年阶段，性别和性别对支气管肺泡和血管室的影响。

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Sex and gender differences during the lung lifespan: unveiling a pivotal impact.

Sex and gender differences significantly influence lung parenchyma development, beginning as early as the embryonic stages of human life. Although this association is well known in the clinical manifestations of some relevant pulmonary diseases, there is less data available regarding their effects on cell biological programmes across different stages of body development. A deep understanding of these mechanisms could help in defining preventive strategies tailored to a fully personalised approach to respiratory medicine. From this perspective, this review aims to analyse the influence of sex and gender on bronchoalveolar and vascular compartments from embryonic and neonatal stages through to adolescence, adulthood and elder age.

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来源期刊

European Respiratory Review Medicine-Pulmonary and Respiratory Medicine

CiteScore

14.40

自引率

1.30%

发文量

审稿时长

24 weeks

期刊介绍： The European Respiratory Review (ERR) is an open-access journal published by the European Respiratory Society (ERS), serving as a vital resource for respiratory professionals by delivering updates on medicine, science, and surgery in the field. ERR features state-of-the-art review articles, editorials, correspondence, and summaries of recent research findings and studies covering a wide range of topics including COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis, and pulmonary infections. Articles are published continuously and compiled into quarterly issues within a single annual volume.