先进的影像学评估狼疮关节炎：系统的文献回顾和荟萃分析

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-14 DOI:10.1016/j.semarthrit.2025.152661

Wei Tang , Leila Khalili , Ruoyi Gong , Maya Souvignier , Xin Wang , Shane Murray , Giovanna Rosas Chavez , Alberto Nordmann-Gomes , Laura Geraldino-Pardilla , Yevgeniya Gartshteyn , Robert Clancy , Mandana Nikpour , Anca Askanase

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引用次数: 0

摘要

高达95%的SLE患者存在关节受累。关节炎是工作致残的主要原因，临床试验中70 - 80%的狼疮患者有活跃的关节表现。目的回顾肌肉骨骼（MSK）超声（US）、磁共振成像（MRI）和光学成像（OI）在SLE手、腕关节炎患者中的应用证据，讨论US、MRI和OI的测量特性，并提供这些研究的综合结果。方法本系统综述使用PubMed、EMBASE和Cochrane图书馆对US、MRI和OI进行了三个单独的人群、干预、比较物和结果结构化（PICOS）文献检索。在2019年1月1日至2024年3月31日期间，对US的搜索被限制。结果在502篇鉴定的MSK US中，有16篇被纳入。在2101篇MRI鉴定的文章中，只有8篇被纳入。在已确定的20篇OI文章中，有1篇被包括在内。使用MSK US、MRI和OI的数据分别评估报告的成像异常、这些异常的定义和评分以及测量特性。合并分析显示关节炎/关节痛与US滑膜炎（10.89[4.02,29.48]）和腱鞘炎（5.93[1.99,17.72]）有很强的相关性；当仅限于医生确诊的关节炎时，关节症状与US滑膜炎的相关性降至5.00（1.11,22.60）。结论：目前系统的文献综述检查了使用先进成像方式评估SLE手和手腕受累的可用信息。这篇文献综述表明，需要进一步的研究来证实先进的影像学作为SLE患者MSK表现的结果测量。

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Advanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis

Introduction

Joint involvement is present in up to 95 % of patients with SLE. Arthritis is a main cause of work-related disability and 70–80 % of lupus patients in clinical trials have active joint manifestations.

Objective

To review the evidence on the application of musculoskeletal (MSK) ultrasound (US), magnetic resonance imaging (MRI), and optical imaging (OI) in patients with SLE hand and wrist arthritis, discuss measurement properties of US, MRI, and OI, and to provide combined results from these studies.

Methods

For this systematic review, three separate population, intervention, comparator, and outcome structured (PICOS) literature searches were conducted for US, MRI and OI using PubMed, EMBASE and the Cochrane Library. The search for US was restricted for the period Jan 1, 2019, to March 31, 2024.

Results

Of the 502 identified articles for MSK US, 16 were included. Of the 2101 identified articles for MRI, only 8 were included. Of the 20 identified articles for OI, 1 was included. Data on the use of MSK US, MRI, and OI were evaluated separately regarding reported imaging abnormalities, the definition and scoring of these abnormalities, and measurement properties. Pooled analysis showed strong association between arthritis/arthralgia and US synovitis (10.89 [4.02, 29.48]) and tenosynovitis (5.93 [1.99, 17.72]); association between joint symptoms and US synovitis decreased to 5.00 (1.11, 22.60) when restricted to physician confirmed arthritis.

Conclusion

The current systematic literature review examined available information on the use of advanced imaging modalities in the evaluation of hand and wrist involvement in SLE. This literature review demonstrates the need for further research to substantiate the use of advanced imaging as an outcome measure for the MSK manifestations in patients with SLE.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.