光氧化还原催化烯丙基C-H氟磺化：获得烯丙基磺酰氟

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-06 DOI:10.1021/acs.orglett.5c0001510.1021/acs.orglett.5c00015

Zhi-Min Yan, Chun-Fang Zhang*, Hua Li, Jia-Hua Yang, Lin Qi, Yu-Xue Ma, Yi-Chen Dong, Wei Li* and Li-Jing Wang*,

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引用次数: 0

摘要

本研究报道了一种新的和前所未有的光氧化催化方案，用于直接烯丙基C-H氟磺化烯烃与FABI。这种温和的方案表现出与各种官能团的良好相容性，广泛的底物范围和有前途的可扩展性，能够方便地获得具有特殊区域选择性的广泛的烯丙基磺酰氟化合物。天然产物的后期功能化及其通过SuFEx化学与其他药物的连接进一步证明了该策略的合成稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoredox-Catalyzed Allylic C–H Fluorosulfonylation of Alkenes: Accessing Allyl Sulfonyl Fluorides

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Photoredox-Catalyzed Allylic C–H Fluorosulfonylation of Alkenes: Accessing Allyl Sulfonyl Fluorides

This study reported a novel and unprecedented photoredox-catalyzed protocol for direct allylic C–H fluorosulfonylation of alkenes with FABI. This mild protocol exhibited excellent compatibility with various functional groups, broad substrate scope, and promising scalability, enabling convenient access to a wide range of allyl sulfonyl fluorides with exceptional regioselectivity. The synthetic robustness of this strategy was further demonstrated by the late-stage functionalization of natural products and their ligation with other drugs via SuFEx chemistry.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.