将表观遗传带入太空时代：三维基因组组织是建立表观遗传记忆所必需的证据

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-02-20 DOI:10.1016/j.molcel.2025.01.033

Jessica J. Hawes, Alyson Ashe

引用次数: 0

摘要

在这期杂志上，Fitz-James等人1利用基因操作表明，由转录因子GAF介导的远端调控元件之间的短暂染色体间接触可以启动D. melanogaster的跨代表观遗传。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Moving epigenetic inheritance into the space age: Evidence that 3D genome organization is required for the establishment of epigenetic memory

In this issue, Fitz-James et al.¹ use genetic manipulations to show that transient interchromosomal contacts between distant regulatory elements, mediated by the transcription factor GAF, can initiate transgenerational epigenetic inheritance in D. melanogaster.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.