通过DNA和RNA甲基化的直接串扰调节基因转录

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-02-20 DOI:10.1016/j.molcel.2025.01.030

Xiaoqian Deng, Guoping Fan

引用次数: 0

摘要

在最近的一项Cell研究中，1 Quarto等人揭示了METTL3-METTL14-DNMT1轴在胚胎干细胞（ESC）分化过程中微调基因表达的机制。这项工作强调了表观遗传学和表转录组学之间的相互作用，揭示了DNA和RNA的甲基化如何协调调节分化基因的子集。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tuning up gene transcription via direct crosstalk of DNA and RNA methylation

In a recent Cell study,¹ Quarto et al. uncovered a mechanism by which the METTL3-METTL14-DNMT1 axis fine-tunes gene expression during embryonic stem cell (ESC) differentiation. This work highlights the interplay between epigenetics and epitranscriptomics, shedding light on how methylation of DNA and RNA coordinately regulates a subset of differentiation genes.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.