- Book学术

发布求助

文献互助智能选刊最新文献

Frontiers in epidemiology Pub Date : 2025-02-04 eCollection Date: 2024-01-01 DOI:10.3389/fepid.2024.1503261

Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen

{"title":"The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study.","authors":"Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen","doi":"10.3389/fepid.2024.1503261","DOIUrl":null,"url":null,"abstract":"Background: Obesity is closely associated with lipid metabolism, and the accumulation of lipids leads to low-level inflammation in the body, which can trigger cardiovascular disease. This study aimed to explore the association between a novel marker of lipid accumulation, the abdominal volume index (AVI), inflammatory parameters, and mortality.Methods: This study enrolled 2,109 older adult senior citizens (aged over 60 years) with hypertension from the National Health and Nutrition Examination Survey. The primary endpoints included all-cause mortality and cardiovascular mortality, which were assessed by linking the data to the National Death Index records. Cox regression model and subgroup analysis were constructed to investigate the associations between AVI and both all-cause and cardiovascular mortality. Restricted cubic splines were employed to further explore the relationships among AVI, inflammatory parameters, and mortality. By considering inflammatory factors as mediators, we investigate the mediating effects of AVI on mortality.Results: After a median follow-up of 69 months, there were 1,260 deaths, with 337 attributed to cardiovascular causes within the older adult population studied. In the multivariable-adjusted model, AVI was positively associated with both all-cause and cardiovascular mortality [Hazard Ratio (HR) = 1.09, 95% CI = 1.06-1.11 for all-cause mortality; HR = 1.07, 95% CI = 1.03-1.12 for cardiovascular mortality]. Kaplan-Meier survival plots indicated an overall median survival time of 144 months. Mediation analysis revealed that Systemic Inflammatory Response Index (SIRI), Monocyte-to-HDL ratio (MHR), and Neutrophil-to-Lymphocyte ratio (NLR) mediated 27.15%, 35.15%, and 16.55%, respectively, of the association between AVI and all-cause mortality.Conclusion: AVI is positively associated with all-cause mortality in older adults with hypertension, and this association appears to be partially mediated by inflammatory parameters.","PeriodicalId":73083,"journal":{"name":"Frontiers in epidemiology","volume":"4 ","pages":"1503261"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832662/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fepid.2024.1503261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景：肥胖与脂质代谢密切相关，脂质堆积会导致体内低水平炎症，从而诱发心血管疾病。本研究旨在探讨脂质堆积的新型标志物--腹部容积指数（AVI）、炎症指标和死亡率之间的关联：这项研究从美国国家健康与营养调查中选取了 2,109 名患有高血压的成年老年人（60 岁以上）。主要终点包括全因死亡率和心血管死亡率，通过将这些数据与国家死亡指数记录联系起来进行评估。为研究 AVI 与全因死亡率和心血管死亡率之间的关系，建立了 Cox 回归模型并进行了亚组分析。为了进一步探讨 AVI、炎症参数和死亡率之间的关系，还采用了限制性三次样条。通过将炎症因素视为中介因素，我们研究了 AVI 对死亡率的中介效应：中位随访时间为 69 个月，在研究的老年人群中，有 1,260 人死亡，其中 337 人死于心血管疾病。在多变量调整模型中，AVI 与全因死亡率和心血管死亡率均呈正相关[全因死亡率的危险比 (HR) = 1.09，95% CI = 1.06-1.11；心血管死亡率的危险比 (HR) = 1.07，95% CI = 1.03-1.12]。Kaplan-Meier生存图显示，总体中位生存时间为144个月。中介分析显示，全身炎症反应指数（SIRI）、单核细胞与高密度脂蛋白比率（MHR）和中性粒细胞与淋巴细胞比率（NLR）分别介导了 AVI 与全因死亡率之间 27.15%、35.15% 和 16.55% 的关联：结论：AVI 与患有高血压的老年人的全因死亡率呈正相关，而这种关联似乎部分由炎症参数介导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study.

Background: Obesity is closely associated with lipid metabolism, and the accumulation of lipids leads to low-level inflammation in the body, which can trigger cardiovascular disease. This study aimed to explore the association between a novel marker of lipid accumulation, the abdominal volume index (AVI), inflammatory parameters, and mortality.

Methods: This study enrolled 2,109 older adult senior citizens (aged over 60 years) with hypertension from the National Health and Nutrition Examination Survey. The primary endpoints included all-cause mortality and cardiovascular mortality, which were assessed by linking the data to the National Death Index records. Cox regression model and subgroup analysis were constructed to investigate the associations between AVI and both all-cause and cardiovascular mortality. Restricted cubic splines were employed to further explore the relationships among AVI, inflammatory parameters, and mortality. By considering inflammatory factors as mediators, we investigate the mediating effects of AVI on mortality.

Results: After a median follow-up of 69 months, there were 1,260 deaths, with 337 attributed to cardiovascular causes within the older adult population studied. In the multivariable-adjusted model, AVI was positively associated with both all-cause and cardiovascular mortality [Hazard Ratio (HR) = 1.09, 95% CI = 1.06-1.11 for all-cause mortality; HR = 1.07, 95% CI = 1.03-1.12 for cardiovascular mortality]. Kaplan-Meier survival plots indicated an overall median survival time of 144 months. Mediation analysis revealed that Systemic Inflammatory Response Index (SIRI), Monocyte-to-HDL ratio (MHR), and Neutrophil-to-Lymphocyte ratio (NLR) mediated 27.15%, 35.15%, and 16.55%, respectively, of the association between AVI and all-cause mortality.

Conclusion: AVI is positively associated with all-cause mortality in older adults with hypertension, and this association appears to be partially mediated by inflammatory parameters.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Frontiers in epidemiology

自引率

0.00%

发文量