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时间问题：阴极经颅直流电刺激对间歇性θ -爆发刺激诱导的初级运动皮层神经可塑性的预处理效应。

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2025-04-01 DOI:10.1016/j.neurom.2025.01.006

Wenjun Dai MSc , Yishu Zhang BSc , Yihui Cheng MSc , Manyu Dong BSc , Yilun Qian BSc , Xinyue Wang BSc , Chuan Guo MSc , Hanjun Liu PhD , Ying Shen PhD

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引用次数: 0

摘要

背景：近年来的研究进展强调了间歇性脉冲刺激（iTBS）和经颅直流电刺激（tDCS）在神经可塑性调节中的相互作用。然而，这些模式在优化可塑性方面的协同潜力，特别是在iTBS前的阴极tDCS预处理，仍然知之甚少。目的：研究阴极高清晰度tDCS （HD-tDCS）预处理对itbs诱导的初级运动皮层神经可塑性的影响。材料和方法：20名健康参与者在随机交叉设计中接受了4次刺激，在阴极HD-tDCS预处理后立即或间隔10分钟和30分钟接受iTBS，另外在假HD-tDCS后立即接受iTBS的对照试验。在基线和iTBS后5、10、15和30分钟测量运动诱发电位（MEPs），以评估神经可塑性的变化。每次治疗间隔≥一周，以防止结转效应。结果：与假手术相比，即时阴极HD-tDCS预处理在iTBS后的所有测量间隔内显著增强了MEPs，持续的神经可塑性持续长达30分钟。与30分钟延迟条件相比，即时预处理在5分钟和10分钟时产生显著的MEP增强。结论：阴极tDCS预处理增强iTBS诱导的神经可塑性的效果随着tDCS与iTBS应用间隔时间的增加而降低。这些发现强调了精确的时间在tDCS预处理中对最大化iTBS神经可塑性效应的重要作用，并为优化神经康复方案提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Timing Matters: Preconditioning Effects of Cathodal Transcranial Direct Current Stimulation on Intermittent Theta-Burst Stimulation-Induced Neuroplasticity in the Primary Motor Cortex

Background

Recent advances have highlighted the interplay between intermittent theta-burst stimulation (iTBS) and transcranial direct current stimulation (tDCS) in neuroplasticity modulation. However, the synergistic potential of these modalities in optimizing plasticity, particularly with cathodal tDCS preconditioning before iTBS, remains poorly understood.

Objective

This study examined the effects of cathodal high-definition tDCS (HD-tDCS) preconditioning on iTBS-induced neuroplasticity in the primary motor cortex at different timing intervals.

Materials and Methods

Twenty healthy participants underwent four stimulation sessions in a randomized cross-over design, receiving iTBS either immediately or at 10-minute and 30-minute intervals after cathodal HD-tDCS preconditioning, in addition to a control session with iTBS immediately after sham HD-tDCS. Motor evoked potentials (MEPs) were measured at baseline and 5, 10, 15, and 30 minutes after iTBS to assess changes in neuroplasticity. Each session was separated by ≥one week to prevent carry-over effects.

Results

Compared with sham sessions, immediate cathodal HD-tDCS preconditioning significantly enhanced MEPs across all measured intervals after iTBS, with sustained neuroplasticity persisting for up to 30 minutes. Immediate preconditioning produced significant MEP enhancements at 5 and 10 minutes when compared with the 30-minute delayed condition.

Conclusions

The effectiveness of cathodal tDCS preconditioning in enhancing iTBS-induced neuroplasticity decreased with increasing intervals between tDCS and iTBS application. These findings highlight the essential role of precise timing in tDCS preconditioning for maximizing the neuroplastic effects of iTBS and offer valuable insights for optimizing neurorehabilitation protocols.

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来源期刊

Neuromodulation

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.

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