Yuliya Kupriyanova, Iryna Yurchenko, Pavel Bobrov, Frederik Bartels, Stefan Wierichs, Marc Jonuscheit, Benedict Korzekwa, Katsiaryna Prystupa, Martin Schön, Dania Mendez, Sandra Trenkamp, Volker Burkart, Robert Wagner, Vera Schrauwen-Hinderling, Michael Roden
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引用次数: 0
摘要
本研究旨在评估COVID-19对2型糖尿病患者肝脂质（HL）含量、纤维化风险和肥胖的影响。研究设计和方法：研究对象为2型糖尿病患者，伴有轻度COVID-19病史（n=15，年龄58±12岁，体重指数30.9±5.2 kg/m2），分别在COVID-19恢复前（基线）和恢复后1年（12±2个月）进行检查。对代谢风险变化的调查包括临床检查、空腹血液采样和基于核磁共振的测量。在同一时间内未感染COVID-19的一组参与者（n=14, 61±6年，30.0±4.6 kg/m2）中，根据各自参数的时间过程对潜在变化进行校正。结果：COVID-19导致HL含量相对增加56% (95% CI 18%, 106%；p=0.04)，以质子密度脂肪分数（HL-PDFF）测量，在没有COVID-19的情况下进行时间过程校正。虽然肝脏硬度和体积没有变化，但观察到细胞内脂质、全身、皮下和内脏脂肪组织体积以及胰岛素抵抗和β细胞功能的稳态模型评估。结论：2型糖尿病患者的COVID-19病史与感染恢复1年后较高的HL-PDFF相关。试验注册号：NCT01055093。
Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes.
Introduction: The study aimed to assess the effect of COVID-19 on hepatic lipid (HL) content, fibrosis risk, and adiposity in persons with type 2 diabetes.
Research design and methods: Participants with type 2 diabetes with a history of mild COVID-19 (n=15, age 58±12 years, body mass index 30.9±5.2 kg/m2) were examined before (baseline) and 1 year (12±2 months) after (follow-up) recovery from COVID-19. Investigations for changes in metabolic risk comprised clinical examination, fasting blood sampling and MR-based measurements. Potential changes were corrected with the time course of the respective parameters in a group of participants who did not contract COVID-19 over the same time course (n=14, 61±6 years, 30.0±4.6 kg/m2).
Results: COVID-19 resulted in a relative increase in HL content of 56% (95% CI 18%, 106%; p=0.04) measured as proton density fat fraction (HL-PDFF), corrected for the time course in the absence of COVID-19. While no changes in hepatic stiffness and volume, intramyocellular lipids, whole-body, subcutaneous and visceral adipose tissue volumes as well as homeostatic model assessment of insulin resistance and beta-cell function were observed.
Conclusions: History of COVID-19 in persons with type 2 diabetes is associated with higher HL-PDFF after 1 year following recovery from infection.
期刊介绍：
BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of
high-quality — and evidence-based — original research articles.
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