可见光诱导W/Cr协同催化非活化烷烃的宝石二氟烯基化。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-28 Epub Date: 2025-02-19 DOI:10.1021/acs.orglett.5c00464

Zhijie Zhang, Yue Zhang, Xinyu Xie, Hua-Wei Liu, Tianshuai Zhu, Jing-Jing Zhang, Meng-Yang Hu, Zhen Chen

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引用次数: 0

摘要

目前，Nozaki-Hiyama-Kishi （NHK）反应的范围仅限于醛类和酮类合成醇类衍生物。在这里，我们描述了一个可见光诱导的W/Cr（III）催化的非活化环烷烃和线性烷烃的nhk型宝石二氟烯基化反应。该反应具有原料、反应条件温和、官能团耐受性广等优点。机理研究表明，还原十钨酸盐W10O325-有利于将CrCl3还原为CrCl2，从而关闭催化循环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes.

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Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes.

Currently, the scope of the Nozaki-Hiyama-Kishi (NHK) reaction is limited to aldehydes and ketones to construct alcohol derivatives. Herein, we have described a visible-light-induced synergistic W/Cr(III)-catalyzed NHK-type gem-difluoroallylation reaction of unactivated cyclic and linear alkanes. The reaction merits feedstock materials, mild reaction conditions, and a wide functionality tolerance. Mechanistic studies imply the favorable reduction of CrCl₃ to CrCl₂ by reduced decatungstate W₁₀O₃₂^5-, thus closing the catalytic cycle.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.