通过aza -角三醌策略的外周衍生构建达芙龙胺B的四环核心框架。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-28 Epub Date: 2025-02-19 DOI:10.1021/acs.orglett.4c04548

Huijuanzi Rao, Bin-Bin Deng, Peijie Sun, Qidong Xia, Hanfeng Ding

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引用次数: 0

摘要

介绍了达芙龙胺B高功能化四环核心骨架的合成路线。该策略的主要特点包括氧化脱芳化诱导的[4+2]环加成、二π-甲烷重排和合环复分解反应。我们的方法能够可靠地构建一个完整的四环前体，这反过来又为进一步细化目标分子提供了有价值的功能处理。

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Forging the Tetracyclic Core Framework of Daphlongamine B Enabled by a Peripheral Derivation of the Aza-Angular Triquinane Strategy.

A synthetic route to the highly functionalized tetracyclic core framework of daphlongamine B is described. Key features of the strategy involve an oxidative dearomatization-induced [4+2] cycloaddition, a di-π-methane rearrangement, and a ring-closing metathesis reaction. Our approach enables the reliable construction of a fully elaborated tetracyclic precursor, which, in turn, provides valuable functional handles for further elaboration to the target molecule.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.