右美托咪定对实验性败血症大鼠肝损伤的影响:组织病理学和免疫组织化学研究。

Ömer Faruk Keleş, Havva Sayhan Kaplan, Hacı Ahmet Çiçek, Onur Palabiyik, Zabit Yener
{"title":"右美托咪定对实验性败血症大鼠肝损伤的影响:组织病理学和免疫组织化学研究。","authors":"Ömer Faruk Keleş, Havva Sayhan Kaplan, Hacı Ahmet Çiçek, Onur Palabiyik, Zabit Yener","doi":"10.14744/tjtes.2025.55338","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In the rat sepsis model, the protective effect of dexmedetomidine (Dex) in sepsis-induced tissue injuries by reducing inflammation is still unclear, and research is ongoing to determine whether Dex modulates sepsis-induced tissue injury. To investigate the effect of Dex on liver injury in sepsis rats histopathologically and immunohistochemically.</p><p><strong>Methods: </strong>In this study, sepsis was induced in rats by 10 ml/kg E. coli injection and the protective efficacy of Dex against liver damage was investigated with histopathological and immunohistochemical findings by intraperitoneal administration of 100 mcg/kg Dex.</p><p><strong>Results: </strong>In our results, the most striking and basic morphological changes in the liver tissues of sepsis group rats were neutrophil leukocyte infiltrations in and around the vessels. In Dex-treated groups, neutrophil leucocyte infiltrations were more prominent and marked dilatations were observed in the vessels. The fact that inflammatory reactions were more prominent in the Dex-treated groups was thought to be related to the increase in vascular permeability due to Dex's vasodilation effect.</p><p><strong>Conclusion: </strong>according to the histopathological and immunohistochemical findings obtained in the present study, we conclude that Dex did not alleviate sepsis-induced liver inflammation in a rat sepsis model.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 2","pages":"112-118"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843427/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effects of dexmedetomidine on liver injury in rats with experimental sepsis: A histopathological and immunohistochemical study.\",\"authors\":\"Ömer Faruk Keleş, Havva Sayhan Kaplan, Hacı Ahmet Çiçek, Onur Palabiyik, Zabit Yener\",\"doi\":\"10.14744/tjtes.2025.55338\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In the rat sepsis model, the protective effect of dexmedetomidine (Dex) in sepsis-induced tissue injuries by reducing inflammation is still unclear, and research is ongoing to determine whether Dex modulates sepsis-induced tissue injury. To investigate the effect of Dex on liver injury in sepsis rats histopathologically and immunohistochemically.</p><p><strong>Methods: </strong>In this study, sepsis was induced in rats by 10 ml/kg E. coli injection and the protective efficacy of Dex against liver damage was investigated with histopathological and immunohistochemical findings by intraperitoneal administration of 100 mcg/kg Dex.</p><p><strong>Results: </strong>In our results, the most striking and basic morphological changes in the liver tissues of sepsis group rats were neutrophil leukocyte infiltrations in and around the vessels. In Dex-treated groups, neutrophil leucocyte infiltrations were more prominent and marked dilatations were observed in the vessels. The fact that inflammatory reactions were more prominent in the Dex-treated groups was thought to be related to the increase in vascular permeability due to Dex's vasodilation effect.</p><p><strong>Conclusion: </strong>according to the histopathological and immunohistochemical findings obtained in the present study, we conclude that Dex did not alleviate sepsis-induced liver inflammation in a rat sepsis model.</p>\",\"PeriodicalId\":94263,\"journal\":{\"name\":\"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES\",\"volume\":\"31 2\",\"pages\":\"112-118\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843427/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14744/tjtes.2025.55338\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/tjtes.2025.55338","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effects of dexmedetomidine on liver injury in rats with experimental sepsis: A histopathological and immunohistochemical study.

Background: In the rat sepsis model, the protective effect of dexmedetomidine (Dex) in sepsis-induced tissue injuries by reducing inflammation is still unclear, and research is ongoing to determine whether Dex modulates sepsis-induced tissue injury. To investigate the effect of Dex on liver injury in sepsis rats histopathologically and immunohistochemically.

Methods: In this study, sepsis was induced in rats by 10 ml/kg E. coli injection and the protective efficacy of Dex against liver damage was investigated with histopathological and immunohistochemical findings by intraperitoneal administration of 100 mcg/kg Dex.

Results: In our results, the most striking and basic morphological changes in the liver tissues of sepsis group rats were neutrophil leukocyte infiltrations in and around the vessels. In Dex-treated groups, neutrophil leucocyte infiltrations were more prominent and marked dilatations were observed in the vessels. The fact that inflammatory reactions were more prominent in the Dex-treated groups was thought to be related to the increase in vascular permeability due to Dex's vasodilation effect.

Conclusion: according to the histopathological and immunohistochemical findings obtained in the present study, we conclude that Dex did not alleviate sepsis-induced liver inflammation in a rat sepsis model.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信