探索性高b值弥散加权MR对回盲炎症和肿瘤的定量鉴别。

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-02-17 DOI:10.1186/s13244-025-01916-8

Hao Yu, Yucheng Hai, Jingyu Lu

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引用次数: 0

摘要

目的：探讨高b值（2000 s/mm2）弥散加权成像（DWI）与常规b值（800 s/mm2） DWI鉴别回盲炎性状况及肿瘤的定量分析。方法：66例肿瘤30例，炎性36例，行MR肠造影常规及高b值DWI检查。通过2张b值dwi测量腰肌病变的定量表观扩散系数（ADC）值和信号强度比（SIRs）。应用受试者工作特征（ROC）曲线确定ADC和SIR对肿瘤与炎症的诊断价值。结果：肿瘤的ADC值在800 s/mm2 （p = 0.001）和2000 s/mm2 （p = 0.001和2000 s/mm2 DWI）显著低于炎性病变。高b值DWI的ADC和SIR曲线下面积（AUC）（ADC为0.828，SIR为0.947）优于常规b值DWI（分别为0.731和0.849）。与ADC相比，SIR值在两个b值DWI中都获得了更好的auc。结论：定量ADC值和SIR可作为区分回盲部肿瘤和炎性疾病的非侵入性工具。使用高b值DWI将提高这种能力。此外，高b值DWI获得的SIR是最有希望的定量参数。关键相关声明：本研究表明，定量DWI参数可能作为非侵入性成像生物标志物，用于区分肠道肿瘤和炎症。高b值DWI的SIR可以提高分化，为制定合适的治疗策略提供宝贵的信息。重点：肠道炎症与肿瘤的鉴别仍然是一个难题。定量DWI有助于区分回盲部肿瘤和炎症。DWI的SIR是鉴别这些病理的一个有希望的参数。

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Exploratory high b value diffusion-weighted MR for quantitative differentiation of ileocecal inflammatory conditions and tumors.

Objectives: To explore the quantitative analysis of high b value (2000 s/mm²) diffusion-weighted imaging (DWI) for the differentiation of ileocecal inflammatory conditions and tumors, compared with conventional b value (800 s/mm²) DWI.

Methods: Sixty-six patients with 30 tumors and 36 inflammatory conditions underwent MR enterography with conventional and high b values DWI. Quantitative apparent diffusion coefficient (ADC) values and signal intensity ratios (SIRs) of lesions of the psoas muscle were measured from the two b value DWIs. The receiver operating characteristic (ROC) curve was applied to determine the diagnostic value of ADC and SIR for differentiating tumors from inflammatory conditions.

Results: The ADC values of tumors were significantly lower than those of inflammatory conditions in 800 s/mm² (p = 0.001) and 2000 s/mm² (p < 0.001) DWI. In addition, tumors exhibited significantly higher SIR values compared to inflammatory conditions (p < 0.001 in 800 s/mm² and 2000 s/mm² DWI). Areas under the curve (AUC) of ADC and SIR derived from high b value (0.828 for ADC, 0.947 for SIR) were superior to those from conventional b value DWI (0.731 and 0.849, respectively). Compared to ADC, SIR values achieved better AUCs in both two b values DWI.

Conclusions: Quantitative ADC values and SIR could be used as non-invasive tools to distinguish ileocecal tumors from inflammatory conditions. The use of high b value DWI would improve this ability. Furthermore, SIR obtained from high b value DWI was the most promising quantitative parameter.

Critical relevance statement: This study indicated that quantitative DWI parameters might be applied as non-invasive imaging biomarkers for distinguishing bowel tumors from inflammatory conditions. The SIR from high b value DWI could improve the differentiation, providing invaluable information for establishing appropriate therapeutic strategies.

Key points: Differentiation between bowel inflammatory conditions and tumors is still a dilemma. Quantitative DWI contributed to distinguishing ileocecal tumors from inflammatory conditions. SIR from DWI is a promising parameter for differentiating these pathologies.

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.