新型异汀类药物的 MCRs:新型噻嗪类药物的绿色合成与理论研究

IF 2.4 3区 化学 Q2 CHEMISTRY, ORGANIC
Fahimeh Alirezapour , Fatemeh Sheikholeslami-Farahani , Majid Moradian , Maryam Ghazvini
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Novel MCRs of Isatins: Green Synthesis and Theoretical Study of Novel Thiazinoazepines
This study examined the utilization of an intricate procedure including isatin, α-haloketones, electron-deficient acetylenic chemicals, ammonium acetate, and isothiocyanates in an aqueous solution at standard room temperature. The objective was to produce new thiazinoazepine compounds with substantial yields. The synthesized thiazinoazepines possess NH functional groups with acidic protons and exhibit significant antioxidant action. The synthesized compounds demonstrated antibacterial efficacy against both Gram-positive and Gram-negative bacteria, as evaluated by the disk diffusion method. Quantum chemical methods based on density functional theory have been employed to improve understanding of reaction mechanisms. The employed methodology for the synthesis of thiazinoazepines offers numerous benefits, such as swift reaction kinetics, exceptional product yield, and uncomplicated product isolation.
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来源期刊
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds 化学-有机化学
CiteScore
3.70
自引率
20.80%
发文量
412
审稿时长
3 months
期刊介绍: The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.
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