谷胱甘肽在谷胱唑啉teredinibactin生物合成中的作用

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-17 DOI:10.1021/acs.orglett.4c04336

Youjung Sung, Bailey W. Miller, Eric W. Schmidt

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引用次数: 0

摘要

Teredinibactins是由海洋中船虫共生体teredinibacterturnerae T7901合成的β-再环噻唑啉二肽。通过饲养研究，我们发现噻唑啉部分是由谷胱甘肽及其代谢物通过非规范途径合成的，我们建议将其命名为“谷胱甘肽”。模拟生物合成反应，我们合成了天然和非天然的teredinibactin。该结果扩大了芳香偶氮啉缀合物的生物和化学途径的范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Glutathione in the Biosynthesis of Glutazoline Teredinibactins

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Glutathione in the Biosynthesis of Glutazoline Teredinibactins

Teredinibactins are β-resorcyclic thiazoline dipeptides synthesized by Teredinibacter turnerae T7901, a bacterial symbiont of shipworms in the sea. Through feeding studies, we show that the thiazoline moiety is made from glutathione and its metabolites in a noncanonical pathway, for which we suggest the name “glutazoline”. Mimicking the biosynthetic reaction, we synthesized both natural and unnatural teredinibactins. The results expand the scope of biological and chemical approaches to aromatic azoline conjugates.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.