Patryk Filipiak, Timothy M Shepherd, Lee Basler, Anthony Zuccolotto, Dimitris G Placantonakis, Walter Schneider, Fernando E Boada, Steven H Baete
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Diffusion phantom study of fiber crossings at varied angles reconstructed with ODF-Fingerprinting.
White matter fiber reconstructions based on seeking local maxima of Orientation Distribution Functions (ODFs) typically fail to identify fibers crossing at narrow angles below 45°. ODF-Fingerprinting (ODF-FP) replaces the ODF maxima localization mechanism with pattern matching, allowing the use of all information stored in ODFs. In this work, we study the ability of ODF-FP to reconstruct fibers crossing at varied angles spanning 10°-90° in physical diffusion phantoms composed of textile tubes with 0.8μm diameter, approaching the anatomical scale of axons. Our results show that ODF-FP is able to correctly identify 80 ± 8% of the crossing fibers regardless of the crossing angle and provide the highest average reconstruction accuracy.
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