空腹血糖受损或2型糖尿病与败血症之间的联系:来自国家健康筛查队列的10年观察数据

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2025-05-01 Epub Date: 2025-02-17 DOI:10.4093/dmj.2024.0387
Eun Hwa Lee, Kyoung Hwa Lee, Kyu-Na Lee, Yebin Park, Kyung Do Han, Sang Hoon Han
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引用次数: 0

摘要

背景:无直接药物治疗的败血症死亡率高。基于单次空腹血糖(FG)的前驱糖尿病或长期2型糖尿病(T2DM)与败血症之间的关系尚不清楚。方法:在2009年纳入国家健康筛查计划(NHSP)的20岁以上成年人中,随机抽取40%。在排除1型糖尿病患者、信息缺失患者和在洗脱期(2001年至NHSP)或1年滞后期被诊断为败血症的患者后,该队列包括3,863,323名受试者。进行了身体质量指数(BMI)测量、FG测试和健康相关行为的自我报告问卷。个人信息随访至2020年,并在首次发生败血症或死亡时进行审查。脓毒症的发生率采用多变量回归进行比较,校正了年龄、性别、收入、BMI、吸烟、饮酒、体力活动水平和慢性疾病。结果:该队列分为血糖正常(n=2,675,476)、空腹血糖(IFG)受损(n=890,402, 23.0%)和T2DM患者。结论:长期和年轻发病的T2DM患者出现败血症的风险相当高,强调了预防感染和接种疫苗的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Connection between Impaired Fasting Glucose or Type 2 Diabetes Mellitus and Sepsis: A 10-Year Observational Data from the National Health Screening Cohort.

Backgruound: The mortality of sepsis without direct drugs is high. The association between prediabetes, based on a single fasting glucose (FG), or long-term type 2 diabetes mellitus (T2DM) and sepsis remains unclear.

Methods: Of the adults aged ≥20 years who were included in the National Health Screening Program (NHSP) in 2009, 40% were randomly sampled. After excluding patients with type 1 diabetes mellitus, with missing information, and who were diagnosed with sepsis during the wash-out (between 2001 and the NHSP) or 1-year lag period, a cohort comprised of 3,863,323 examinees. Body mass index (BMI) measurements, FG tests, and self-reported questionnaires on health-related behaviors were conducted. Individual information was followed up until 2020 and censored upon the first occurrence of sepsis or death. The incidence of sepsis was compared using a multivariable regression adjusted for age, sex, income, BMI, smoking, drinking, physical activity levels, and chronic diseases.

Results: The cohort was divided into those with normal FG (n=2,675,476), impaired fasting glucose (IFG) (n=890,402, 23.0%), T2DM <5 years (n=212,391, 5.5%), or T2DM for ≥5 years (n=85,054, 2.2%). The groups with IFG (adjusted hazard ratio [aHR], 1.03; 95% confidence interval [CI], 1.01 to 1.05), T2DM <5 years (aHR, 1.43; 95% CI, 1.40 to 1.47), and T2DM for ≥5 years (aHR, 1.82; 95% CI, 1.77 to 1.87) exhibited significantly higher incidence of sepsis (P<0.001), with the greatest risk in patients with T2DM aged <40 years (aHR, 1.96; 95% CI, 1.71 to 2.25).

Conclusion: Patients with long-standing and young-onset T2DM show a substantially high risk of sepsis, emphasizing the need for infection prevention and vaccination.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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