Keyi Bian, Yueqiang Zhu, Yafei Wang, Yue Ma, Zhaoxiang Ye
{"title":"与乳腺癌患者淋巴管受侵相关的锥形束乳腺 CT 特征","authors":"Keyi Bian, Yueqiang Zhu, Yafei Wang, Yue Ma, Zhaoxiang Ye","doi":"10.1016/j.acra.2025.01.005","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale and objectives: </strong>To explore the association between contrast-enhanced cone-beam breast CT (CE-CBBCT) imaging features and lymphovascular invasion (LVI) status.</p><p><strong>Materials and methods: </strong>Female patients with breast cancer by postoperative histopathology who underwent preoperative CE-CBBCT from August 2020 to December 2023 were retrospectively enrolled. Two radiologists reviewed the CBBCT image features independently. Clinicopathologic and CBBCT characteristics between LVI-positive and LVI-negative were compared by χ2 or Fisher's exact tests and Student's t or Mann-Whitney U test, as appropriate. Multivariate logistic regression analysis was performed to identify independent predictive factors of LVI. The receiver operating characteristic curve was used to evaluate predictive performance.</p><p><strong>Results: </strong>A total of 401 women were enrolled. LVI status of breast cancer was significantly associated with histologic type, Ki-67 index, adjacent vessel sign (AVS), increased ipsilateral whole-breast vascularity (IIV) number, and IIV degree (all p<0.05). In mass, calcification, AVS, IIV number, and IIV degree were significantly associated with LVI (all p<0.05). In non-mass enhancement (NME), AVS, IIV number, and IIV degree were associated with LVI (all p<0.05). Multivariate logistic regression showed AVS (OR=4.367, p<0.001) and IIV degree (OR of moderate and prominent IIV=4.732, 3.641, both p<0.005) as independent risk factors for LVI. Specifically, in mass, AVS (OR=4.397, p<0.001) and moderate-to-prominent IIV (OR=4.815, 3.563, both p<0.01) were independent predictors. For NME, moderate-to-prominent IIV (OR=13.695, 4.054, both p=0.001) was also an independent factor. The combined LVI prediction model which included AVS and IIV degree showed excellent performance (AUC=0.804).</p><p><strong>Conclusion: </strong>CBBCT imaging features can help identify LVI status in breast cancer patients, which will guide the accurate planning of treatment management.</p>","PeriodicalId":50928,"journal":{"name":"Academic Radiology","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cone-beam Breast CT Features Associated With Lymphovascular Invasion in Patients With Breast Cancer.\",\"authors\":\"Keyi Bian, Yueqiang Zhu, Yafei Wang, Yue Ma, Zhaoxiang Ye\",\"doi\":\"10.1016/j.acra.2025.01.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale and objectives: </strong>To explore the association between contrast-enhanced cone-beam breast CT (CE-CBBCT) imaging features and lymphovascular invasion (LVI) status.</p><p><strong>Materials and methods: </strong>Female patients with breast cancer by postoperative histopathology who underwent preoperative CE-CBBCT from August 2020 to December 2023 were retrospectively enrolled. Two radiologists reviewed the CBBCT image features independently. Clinicopathologic and CBBCT characteristics between LVI-positive and LVI-negative were compared by χ2 or Fisher's exact tests and Student's t or Mann-Whitney U test, as appropriate. Multivariate logistic regression analysis was performed to identify independent predictive factors of LVI. The receiver operating characteristic curve was used to evaluate predictive performance.</p><p><strong>Results: </strong>A total of 401 women were enrolled. LVI status of breast cancer was significantly associated with histologic type, Ki-67 index, adjacent vessel sign (AVS), increased ipsilateral whole-breast vascularity (IIV) number, and IIV degree (all p<0.05). In mass, calcification, AVS, IIV number, and IIV degree were significantly associated with LVI (all p<0.05). In non-mass enhancement (NME), AVS, IIV number, and IIV degree were associated with LVI (all p<0.05). Multivariate logistic regression showed AVS (OR=4.367, p<0.001) and IIV degree (OR of moderate and prominent IIV=4.732, 3.641, both p<0.005) as independent risk factors for LVI. Specifically, in mass, AVS (OR=4.397, p<0.001) and moderate-to-prominent IIV (OR=4.815, 3.563, both p<0.01) were independent predictors. For NME, moderate-to-prominent IIV (OR=13.695, 4.054, both p=0.001) was also an independent factor. The combined LVI prediction model which included AVS and IIV degree showed excellent performance (AUC=0.804).</p><p><strong>Conclusion: </strong>CBBCT imaging features can help identify LVI status in breast cancer patients, which will guide the accurate planning of treatment management.</p>\",\"PeriodicalId\":50928,\"journal\":{\"name\":\"Academic Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Academic Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.acra.2025.01.005\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Academic Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.acra.2025.01.005","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Cone-beam Breast CT Features Associated With Lymphovascular Invasion in Patients With Breast Cancer.
Rationale and objectives: To explore the association between contrast-enhanced cone-beam breast CT (CE-CBBCT) imaging features and lymphovascular invasion (LVI) status.
Materials and methods: Female patients with breast cancer by postoperative histopathology who underwent preoperative CE-CBBCT from August 2020 to December 2023 were retrospectively enrolled. Two radiologists reviewed the CBBCT image features independently. Clinicopathologic and CBBCT characteristics between LVI-positive and LVI-negative were compared by χ2 or Fisher's exact tests and Student's t or Mann-Whitney U test, as appropriate. Multivariate logistic regression analysis was performed to identify independent predictive factors of LVI. The receiver operating characteristic curve was used to evaluate predictive performance.
Results: A total of 401 women were enrolled. LVI status of breast cancer was significantly associated with histologic type, Ki-67 index, adjacent vessel sign (AVS), increased ipsilateral whole-breast vascularity (IIV) number, and IIV degree (all p<0.05). In mass, calcification, AVS, IIV number, and IIV degree were significantly associated with LVI (all p<0.05). In non-mass enhancement (NME), AVS, IIV number, and IIV degree were associated with LVI (all p<0.05). Multivariate logistic regression showed AVS (OR=4.367, p<0.001) and IIV degree (OR of moderate and prominent IIV=4.732, 3.641, both p<0.005) as independent risk factors for LVI. Specifically, in mass, AVS (OR=4.397, p<0.001) and moderate-to-prominent IIV (OR=4.815, 3.563, both p<0.01) were independent predictors. For NME, moderate-to-prominent IIV (OR=13.695, 4.054, both p=0.001) was also an independent factor. The combined LVI prediction model which included AVS and IIV degree showed excellent performance (AUC=0.804).
Conclusion: CBBCT imaging features can help identify LVI status in breast cancer patients, which will guide the accurate planning of treatment management.
期刊介绍：
Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.
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