长COVID对炎性关节炎患者自我报告的疾病活动、残疾和生活质量的影响

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-11 DOI:10.1016/j.semarthrit.2025.152657

Zachary S. Wallace , Miao Lin , Shruthi Srivatsan , Andrew King , Xiaosong Wang , Rathnam Venkat , Yumeko Kawano , Madison Negron , Buuthien Hang , Abigail Schiff , Jennifer Hanberg , Emily N. Kowalski , Colebrook Johnson , Kathleen M.M. Vanni , Zachary Williams , Grace Qian , Caleb Bolden , Kevin T. Mueller , Katarina J. Bade , Alene A. Saavedra , Jeffrey A. Sparks

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引用次数: 0

摘要

患有炎症性关节炎的人面临COVID-19预后不佳的风险。人们对长期COVID对这一人群的疾病活动、残疾和生活质量的影响知之甚少。方法：我们纳入了来自rheumatcard的类风湿关节炎、银屑病关节炎、青少年特发性关节炎或轴性脊柱炎患者，这是一项前瞻性队列研究，研究对象是既往有或没有COVID-19的风湿病患者。长COVID定义为急性COVID-19的任何症状持续≥90天。调查包括患者指数数据常规评估3 （RAPID-3）、改良健康评估问卷（MHAQ）、短表12 （SF-12）、疲劳症状量表和短表McGill疼痛问卷。我们评估了长期COVID状态与这些结果的关系。结果n = 59例长冠状病毒感染患者，n = 165例无长冠状病毒感染患者，n = 59例无冠状病毒感染患者。最常见的长时间COVID症状是疲劳（37.3%）、嗅觉/味觉改变（27.1%和25.4%）、呼吸困难（20.3%）和头痛（15.3%）。长冠肺炎患者与未长冠肺炎患者的mHAQ更差(中位数0.4 vs 0.1, p <；0.001)、RAPID-3 （4.0 vs. 2.3, p = 0.0005）和身心健康（SF-12: 37.7 vs. 47.2, p = 0.0003和45.3 vs. 53.0, p = 0.003）。疲劳和疼痛在长冠者和未长冠者中更严重(p <；0.05为比较)。在长冠状病毒感染者与无冠状病毒感染者中观察到类似的趋势。结论长时间的COVID可导致炎性关节炎患者的疼痛、疲劳和生活质量恶化。由于长期COVID的影响，对炎症性关节炎患者报告的结果应谨慎解释。

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Impact of long COVID on self-reported disease activity, disability, and quality of life in individuals with inflammatory arthritis

Background

People with inflammatory arthritis are at risk for poor COVID-19 outcomes. Little is known about the impact of long COVID on disease activity, disability, and quality of life in this population.

Methods

We included participants with rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, or axial spondyloarthritis from RheumCARD, a prospective cohort study of people with rheumatic disease with and without prior COVID-19. Long COVID was defined as any symptom of acute COVID-19 for ≥90 days. Surveys include the Routine Assessment of Patient Index Data 3 (RAPID-3), modified health assessment questionnaire (MHAQ), short form-12 (SF-12), fatigue symptom inventory, and short form McGill Pain Questionnaire. We assessed the association of long COVID status with these outcomes.

Results

We analyzed n = 59 with long COVID, n = 165 without long COVID, and n = 59 without prior COVID-19. The most common long COVID symptoms were fatigue (37.3 %), altered smell/taste (27.1 % and 25.4 %), difficulty breathing (20.3 %), and headache (15.3 %). Those with vs. without long COVID had worse mHAQ (median 0.4 vs. 0.1, p < 0.001), RAPID-3 (4.0 vs. 2.3, p = 0.0005), and physical and mental health (SF-12: 37.7 vs. 47.2, p = 0.0003 and 45.3 vs. 53.0, p = 0.003, respectively). Fatigue and pain were worse in those with vs. without long COVID (p < 0.05 for comparisons). Similar trends were observed in those with long COVID vs. those without prior COVID-19.

Conclusion

Long COVID may result in worsened pain, fatigue, and quality of life in people with inflammatory arthritis. Patient-reported outcomes should be interpreted with caution in people with inflammatory arthritis because of the impact of long COVID.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.