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IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-02-15 DOI:10.1039/d5qo00147a

Guang-Chuan Xu, Liang Zeng, Ming Hu, Fujin Sun, Jin-Heng Li

引用次数: 0

摘要

本研究报告介绍了一种有用的合成方法，即通过碘代芳香烃引导的光氧遥控 C(sp3)-H 杂芳香化邻碘芳香烃-1-酮与杂芳香烃的形式化β-杂芳香化酮。该方案依赖于单电子转移（SET）、氢原子转移（HAT）和双 C-H 功能化，从而得到 β-杂芳基酮。这种温和的方法具有广泛的适用范围、良好的官能团兼容性、高原子经济性和出色的选择性控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photoredox β-C(sp3)-H Heteroarylation of o-Iodoaryl-alkan-1-ones with Heteroarenes via HAT and Dual C-H Functionalizations

A synthetically useful method for the formal β-heteroarylation of ketones via an iodoarene-directed photoredox remote C(sp3)−H heteroarylation of o-iodoarylalkan-1-ones with heteroarenes is reported. This protocol relies on single electron transfer (SET), hydrogen atom transfer (HAT) and dual C-H functionalizations leading to β-heteroaryl ketones. This mild method displays a broad scope, a good functional group compatibility, a high atom economy and an excellent selectivity control.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.