益生菌和胃肠道细菌对幽门螺杆菌的体外抑制作用。

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Digestion Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI:10.1159/000543447
Johannes Raphael Westphal, Nadine Koch, Lukas Macke, Riccardo Vasapolli, Didem Saka, Ramiro Vilchez-Vargas, Tianjun Song, Peter Malfertheiner, Christian Schulz
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引用次数: 0

摘要

简介:幽门螺杆菌是一种高度流行的病原体,影响世界上大约50%的人口,引起慢性胃炎和随后的腺癌。幽门螺杆菌的抗生素耐药率正在增加,因此需要替代治疗方案。一些有益细菌,包括益生菌和胃肠道共生菌,被证明可以抑制幽门螺杆菌的生长、活力和胃上皮的初始附着。方法:本文系统地综述了目前有关乳酸杆菌目有益菌体外抑制幽门螺杆菌的文献。我们按照PRISMA指南在PubMed和谷歌scholar上进行了研究。结果:大量的物种被证明具有抗h。尽管大多数被调查的细菌只属于一种细菌属:乳酸杆菌。Anti-H。幽门螺杆菌的活性是通过毒力因子的转录调节、结合位点的竞争、幽门螺杆菌休眠状态的诱导和抗幽门螺杆菌的分泌来介导的。螺杆菌的化合物。结论:体外实验表明,许多具有益生菌特性的细菌化合物具有抑制幽门螺杆菌的作用。然而,检测抗h抗体的检测方法种类繁多。幽门螺杆菌效应需要标准化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibitory Effects of Probiotic and Gastro-Intestinal Bacteria on Helicobacter pylori in vitro.

Introduction: Helicobacter pylori is a highly prevalent pathogen affecting approximately 50% of the world population, causing chronic gastritis and subsequently adenocarcinoma. Antibiotic resistance rates in H. pylori are increasing, thus demanding alternative treatment options. Some beneficial bacteria, including probiotics and gastrointestinal commensals, were shown to inhibit H. pylori growth, viability, and initial attachment to the gastric epithelium.

Methods: In this review, we systematically summarized the currently available literature for in vitro inhibition of H. pylori through beneficial bacteria from the Lactobacillales order. We performed research on PubMed and Google Scholar in accordance with the PRISMA guidelines.

Results: A multitude of species were shown to possess anti-H. pylori activity, although the majority of investigated bacteria belonged to only one bacterial genus: Lactobacillus. Anti-H. pylori activity was mediated through transcriptional modulation of virulence factors, competition for binding sites, the induction of a dormancy state of H. pylori, and the secretion of anti-H. pylori compounds.

Conclusion: Many bacterial compounds that show probiotic properties are capable of inhibiting H. pylori in in vitro experiments. However, a huge variety of test methods to detect anti-H. pylori effects demands standardization.

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来源期刊
Digestion
Digestion 医学-胃肠肝病学
CiteScore
7.90
自引率
0.00%
发文量
39
审稿时长
6-12 weeks
期刊介绍: ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.
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