Naruchorn Kijpaisalratana, Chia-Ling Phuah, Zsuzsanna Ament, Varun M Bhave, Ana-Lucia Garcia-Guarniz, Jonathan Duskin, Catharine A Couch, M Ryan Irvin, W Taylor Kimberly
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However, it is unclear if gut metabolites and WMH interact to influence dementia.</p><p><strong>Objectives: </strong>To examine the association between gut microbial metabolites and cognitive outcomes and assess whether the severity of baseline WMH would impact associations between gut microbial metabolites and cognitive outcomes.</p><p><strong>Design: </strong>Cross-sectional design.</p><p><strong>Setting: </strong>Cohort of individuals who are clinically normal, mild cognitive impairment, or Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI).</p><p><strong>Participants: </strong>A total of 578 participants with available baseline 3.0T 2D-Fluid Attenuation Inversion Recovery (FLAIR) Magnetic Resonance Imaging (MRI) scans and baseline gut microbial metabolite measurement were included in the analysis.</p><p><strong>Measurements: </strong>Gut metabolite measurements and automated WMH volume estimations were obtained from FLAIR MRI and were used to assess the association and interaction with cognitive impairment.</p><p><strong>Results: </strong>Of 104 metabolites studied, glycodeoxycholic acid (GDCA) surpassed the false discovery rate and was associated the Alzheimer's Disease Assessment Scale-Cognitive Subscale version 13 (ADAS-Cog13) score (β = 0.12, 95 % CI = 0.05-0.20, p = 0.001) and cognitive impairment determined by mini-mental status exam (MMSE) (OR = 2.11, 95 % CI = 1.41-3.15, p < 0.001). GDCA was associated with higher ADAS-Cog13 in participants with low WMH burden (β = 0.21, 95% CI = 0.10-0.32, p < 0.001) but not in participants with high WMH burden (β = 0.04, 95 % CI = -0.07 to 0.14, p = 0.48; interaction p = 0.02).</p><p><strong>Conclusion: </strong>An elevated level of GDCA was associated with worse cognition. 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引用次数: 0
摘要
背景：肠道微生物相关代谢物和白质高强度（WMH）与认知障碍独立相关。然而，肠道代谢物和WMH是否相互作用影响痴呆尚不清楚。目的：研究肠道微生物代谢物与认知结果之间的关系，并评估基线WMH的严重程度是否会影响肠道微生物代谢物与认知结果之间的关系。设计：横断面设计。背景：阿尔茨海默病神经影像学倡议（ADNI）中临床正常、轻度认知障碍或阿尔茨海默病的个体队列。参与者：共有578名参与者进行了基线3.0T二维流体衰减反转恢复（FLAIR）磁共振成像（MRI）扫描和基线肠道微生物代谢物测量。测量：通过FLAIR MRI获得肠道代谢物测量和自动WMH体积估计，并用于评估与认知障碍的关联和相互作用。结果：在所研究的104种代谢物中，糖去氧化胆酸（GDCA）超过了错误发现率，并与阿尔茨海默病评估量表-认知亚量表第13版（ADAS-Cog13）评分（β = 0.12, 95% CI = 0.05-0.20, p = 0.001）和迷你精神状态检查（MMSE）确定的认知障碍（OR = 2.11, 95% CI = 1.41-3.15, p < 0.001）相关。GDCA与低WMH负担的受试者较高的ADAS-Cog13相关（β = 0.21, 95% CI = 0.10-0.32, p < 0.001），但与高WMH负担的受试者无关(β = 0.04, 95% CI = -0.07 - 0.14, p = 0.48；交互作用p = 0.02)。结论：GDCA水平升高与认知能力下降有关。WMH严重程度改变了GDCA与认知结果之间的关系。
White matter hyperintensity severity modifies gut metabolite association with cognitive outcomes.
Background: Gut microbiome-associated metabolites and white matter hyperintensities (WMH) are independently associated with cognitive impairment. However, it is unclear if gut metabolites and WMH interact to influence dementia.
Objectives: To examine the association between gut microbial metabolites and cognitive outcomes and assess whether the severity of baseline WMH would impact associations between gut microbial metabolites and cognitive outcomes.
Design: Cross-sectional design.
Setting: Cohort of individuals who are clinically normal, mild cognitive impairment, or Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Participants: A total of 578 participants with available baseline 3.0T 2D-Fluid Attenuation Inversion Recovery (FLAIR) Magnetic Resonance Imaging (MRI) scans and baseline gut microbial metabolite measurement were included in the analysis.
Measurements: Gut metabolite measurements and automated WMH volume estimations were obtained from FLAIR MRI and were used to assess the association and interaction with cognitive impairment.
Results: Of 104 metabolites studied, glycodeoxycholic acid (GDCA) surpassed the false discovery rate and was associated the Alzheimer's Disease Assessment Scale-Cognitive Subscale version 13 (ADAS-Cog13) score (β = 0.12, 95 % CI = 0.05-0.20, p = 0.001) and cognitive impairment determined by mini-mental status exam (MMSE) (OR = 2.11, 95 % CI = 1.41-3.15, p < 0.001). GDCA was associated with higher ADAS-Cog13 in participants with low WMH burden (β = 0.21, 95% CI = 0.10-0.32, p < 0.001) but not in participants with high WMH burden (β = 0.04, 95 % CI = -0.07 to 0.14, p = 0.48; interaction p = 0.02).
Conclusion: An elevated level of GDCA was associated with worse cognition. WMH severity modified the association between GDCA and cognitive outcomes.
期刊介绍：
The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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