pd催化/配体控制的烷基烯或芳烯烯的区域选择性不对称氢磺化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-03 DOI:10.1021/acs.orglett.4c0425910.1021/acs.orglett.4c04259

Jing Wu, Boyi Wang, Jinghan Zou, Xinman Guo, Weixing Chang, Lingyan Liu*, Xiaohui Cao* and Jing Li*,

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引用次数: 0

摘要

金属催化的烯丙基加氢功能化反应是构建新型烯丙基化合物的有效途径。本文描述了在Pd2dba3存在下，钯催化/配体控制的简单烷基烯和芳烯烯的不对称氢磺化反应。采用Josiphos或Segphos配体，烷基烯丙烯或芳烯丙烯可合成相应的支链手性烯丙基砜，其产率和对映选择性分别高达90%和99%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes

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Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes

The metal-catalyzed hydrofunctionalization reaction of allenes is an efficient approach for the construction of new allyl compounds. This work described a palladium-catalyzed/ligand-controlled asymmetric hydrosulfonylation of simple alkylallenes and arylallenes in the presence of Pd₂dba₃. Using a Josiphos or Segphos ligand, the alkylallenes or arylallenes could render the corresponding branched chiral allylsulfones with high yields and high enantioselectivities up to 90% and 99% ee, respectively.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.