Pd/手性磷酸激活不对称分子内双碳氢活化反应合成p -立体苯并膦孔氧化物

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-02 DOI:10.1021/acs.orglett.4c0485310.1021/acs.orglett.4c04853

Shao-Bai Yan, Zhen Li, Xian-Qi Hu, Shuwei Zhang and Wei-Liang Duan*,

引用次数: 0

摘要

报道了一种pd催化的分子内不对称双C-H活化反应，并确定了一种基于BINOL骨架的手性磷酸（CPA）是这种转化的合适配体。广泛的p -立体苯并膦孔氧化物以中等至优异的产率合成，具有高水平的对映选择性（≤96% ee）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd/Chiral Phosphoric Acid-Enabled Asymmetric Intramolecular Double C–H Activation Reaction for the Synthesis of P-Stereogenic Benzophosphole Oxides

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Pd/Chiral Phosphoric Acid-Enabled Asymmetric Intramolecular Double C–H Activation Reaction for the Synthesis of P-Stereogenic Benzophosphole Oxides

A Pd-catalyzed intramolecular asymmetric double C–H activation reaction was reported, and a BINOL skeleton-based chiral phosphoric acid (CPA) was identified as a suitable ligand for this transformation. A broad range of P-stereogenic benzophosphole oxides were synthesized in moderate to excellent yield with high levels of enantioselectivity (≤96% ee).

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.