用铜催化苯胺与（杂）芳基氯化物/溴化物偶联组装联芳基胺

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-31 DOI:10.1021/acs.orglett.5c0000410.1021/acs.orglett.5c00004

Sailuo Li, Lanting Xu, Bang An and Dawei Ma*,

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引用次数: 0

摘要

CuI/6-羟基吡啶酰肼催化（杂）芳酰氯与苯胺的偶联反应在100℃下进行得很好，以多种方式产生联芳胺，这是cu在较温和条件下催化联芳胺的第一个例子。同样的催化体系可以使（杂）芳基溴与苯胺在室温下偶联，使相应的产物具有良好的反应范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Assembly of Biaryl Amines via Mild Copper-Catalyzed Coupling of Anilines with (Hetero)aryl Chlorides/Bromides

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Assembly of Biaryl Amines via Mild Copper-Catalyzed Coupling of Anilines with (Hetero)aryl Chlorides/Bromides

CuI/6-hydroxy picolinohydrazide-catalyzed coupling of (hetero)aryl chlorides with anilines proceeded well at 100 °C to afford biaryl amines in a diverse manner, which represents the first example of Cu-catalyzed biaryl amines under milder conditions. The same catalytic system could make the coupling of (hetero)aryl bromides with anilines work at room temperature, giving the corresponding products with an excellent reaction scope.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.