生物催化和光化学形式[2+2]环加成：合成融合五环二萜骨架的途径

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-02 DOI:10.1021/acs.orglett.4c0472410.1021/acs.orglett.4c04724

Fátima Vela Benavides, Marija Kirić, Felipe Escobar-Montaño, Antonio J. Macías-Sánchez, Hernando Bolivar-Anillo, José M. Botubol-Ares*, Rosa Durán-Patrón and Rosario Hernández-Galán*,

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引用次数: 0

摘要

从lathyrane euphobotirane A(1)中得到了一种前所未有的具有五环骨架的新型二萜cycloehohobotirane A(2)，并参与了Sordaria tomento-alba ST1-UCA催化的正式分子内[2+2]环加成反应，为能够催化该反应的酶的存在提供了新的证据。二苯甲酮在发光二极管照射下也实现了仿生光化学转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biocatalyzed and Photochemical Formal [2+2] Cycloaddition of Euphoboetirane A: A Route to a Fused Pentacyclic Diterpene Skeleton

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Biocatalyzed and Photochemical Formal [2+2] Cycloaddition of Euphoboetirane A: A Route to a Fused Pentacyclic Diterpene Skeleton

Cycloeuphoboetirane A (2), a new diterpene with an unprecedented pentacyclic skeleton, has been obtained from lathyrane euphoboetirane A (1). A formal intramolecular [2+2] cycloaddition reaction catalyzed by Sordaria tomento-alba ST1-UCA is involved, providing new evidence for the existence of enzymes capable of catalyzing this reaction. A biomimetic photochemical conversion was also achieved by benzophenone with light-emitting diode irradiation.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.