创伤性脑损伤、肥胖和胰岛素抵抗的相关性——一例报告。

Laura De Wilde, Charlotte De Ruysscher, Kristine Oostra
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引用次数: 0

摘要

外伤性脑损伤是一个重要的全球健康问题。它通常由高速事故引起,并导致弥漫性轴索损伤,引起意识障碍,并可能导致永久性的认知和行为改变。患有创伤性脑损伤的个体通常会表现出体重增加,这可能导致肥胖。这种体重增加受认知功能障碍、体力活动减少和代谢变化的影响。病例报告:一名23岁的女性在交通事故后遭受了创伤性脑损伤,最初的格拉斯哥昏迷评分为5/15。在重症监护病房和神经外科住院期间,观察到积极的神经系统改善。随后,她被转到康复科,在那里她面临着重大挑战,包括情绪波动、认知障碍和体重大幅增加。她的身体质量指数(BMI)从事故前的23 kg/m2增加到最高的36 kg/m2,尽管有药物和生活方式的改变等干预措施。血液测试显示胰岛素抵抗和二甲双胍成功地减轻了体重。结论:创伤性脑损伤后体重增加的控制需要有效的干预措施,包括生活方式的改变、行为治疗和潜在的药物治疗或减肥手术。进一步的研究是必要的,以更好地了解潜在的机制和评估干预的有效性在这一特定的患者群体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CORRELATION BETWEEN TRAUMATIC BRAIN INJURY, OBESITY AND INSULIN-RESISTANCE - A CASE REPORT.

Introduction: Traumatic brain injury is a significant global health concern. It often results from high-velocity accidents and leads to diffuse axonal injury, causing consciousness disorders and potentially permanent cognitive and behavioural changes. Individuals with traumatic brain injury often exhibit weight gain, potentially leading to obesity. This weight increase is influenced by cognitive dysfunction, reduced physical activity and metabolic changes.

Case report: A 23-year-old woman suffered a traumatic brain injury after a traffic accident, with an initial Glasgow Coma Scale score of 5/15. Positive neurological improvement was observed during her stay in the intensive care unit and the neurosurgical department. Subsequently, she was transferred to the rehabilitation department, where she faced significant challenges, including mood fluctuations, cognitive impairments and substantial weight gain. Her body mass index (BMI) increased from 23 kg/m2 pre-accident to a maximum of 36 kg/m2, despite interventions like medications and lifestyle changes. Blood tests revealed insulin-resistance and metformin initiated a successful weight reduction.

Conclusion: Managing weight gain following traumatic brain injury requires effective interventions that acknowledge its complexity and multifaceted nature, including lifestyle modifications, behavioural therapy and potentially pharmacotherapy or bariatric surgery. Further research is essential to better understand underlying mechanisms and evaluate intervention effectiveness in this specific patient population.

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