2020年1月- 2024年7月肝细胞癌中草药和植物化学治疗研究进展

IF 2.6 4区 医学 Q3 CHEMISTRY, MEDICINAL
Zulfa Nooreen, Sunil Harer, Awani Kumar Rai, Ankita Wal, Deepak Nathiya, Parjinder Kaur
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引用次数: 0

摘要

背景:肝细胞癌(HCC)是一种原发性肝脏肿瘤,是仅次于肺癌和结直肠癌的世界第三大恶性肿瘤之一。继胃癌、肺癌和结直肠癌之后,它是癌症相关死亡的最常见原因。自旧石器时代以来,草药就被用作替代药物的重要来源。使用化疗药物的现代癌症治疗是由从植物中提取的化学物质制成的。目的:综述2020年至2024年7月植物化学提取物及分子的研究进展。方法:进行详细的文献调查,收集PubMed、Sci Finder、Science Direct、b谷歌等网站的资料。结果:确定新的治疗方法及其在辅助治疗方面的联合使用可能会解决HCC治疗中未满足的重大需求。这些天对植物进行了大量的研究。植物提取物中包含的许多植物化学物质可能具有抗癌特性,包括诱导细胞周期阻滞、抑制细胞增殖、增加细胞凋亡和阻碍迁移、侵袭和转移的能力。这些方法在HCC中具有更小的危险和更有效的治疗。结论:本文收集了2020年1月至2024年7月植物分子和草药提取物在体外和体内治疗HCC的研究数据。文章还探讨了治疗中涉及的各种机制。研究人员对研究用植物分子治疗HCC的新方法的兴趣正在迅速增长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Insight into Research Advances on Herbal and Phytochemical Approaches to the Management of Hepatocellular Carcinoma from January 2020 to July 2024.

Background: Hepatocellular Carcinoma (HCC) is a primary hepatic tumor and is one of the world's third most frequent malignancies after lung and colorectal. After stomach, lung, and colorectal cancers, it is the most common cause of cancer-related mortality. Since the Palaeolithic era, herbs have been used as an essential source of alternative drugs. Modern cancer treatments that use chemotherapeutic medications are made of chemicals derived from plants.

Objective: The present review is about the compilation of phytochemical extracts and molecules from 2020 to July 2024.

Methods: A detailed literature survey was conducted to compile data from PubMed, Sci Finder, Science Direct, Google, etc. Results: The identification of novel treatments and their combinations for usage in the adjuvant context potentially address significant unmet needs in the management of HCC. A large number of investigations have been carried out these days on plants. Numerous phytochemicals included in plant extract may possess anti-cancer properties, including the ability to induce cell cycle arrest, suppress cell proliferation, increase apoptosis, and obstruct migration, invasion, and metastasis. These approaches possess less hazardous and more effective treatment in HCC.

Conclusion: This article is the compilation of data about research on phytomolecules and herbal extracts from January 2020 to July 2024 for the treatment of HCC in vitro and in-vivo. Various mechanisms involved in the treatment are also explored in the article. The growing interest of researchers in investigating new approaches toward HCC management with phytomolecules is rapidly growing.

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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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