A New Green and Efficient Method for Pyranopyrazoles Synthesis in a Single Pot Using Multiple Components, In Silico Pharmacokinetics with Cytotoxic Assessments

Objective: A multi-component development method that does not include a catalyst has been developed for the environmentally friendly synthesis of pyranopyrazole derivatives containing a thioether bond. Methods: This method includes non-hazardous solvents and catalysts, conducts a basic workup, and achieves quantitative yields to eliminate contaminants. Furthermore, the antifungal and antibacterial characteristics of all the reported compounds were examined. Results and Discussion: Compounds (Ve) and (Vf) demonstrated superior antifungal activity compared to fluconazole against both C. albicans and S. cerevisiae at a concentration of 40 µg/mL. Conclusions: The findings provide evidence that these active chemicals could be a solid foundation for future research into developing novel antioxidant and antibacterial medications.