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IF 0.7 4区化学 Q4 CHEMISTRY, PHYSICAL

Russian Journal of Physical Chemistry A Pub Date : 2025-02-11 DOI:10.1134/S0036024424703096

A. A. Garibyan, E. S. Delyagina, I. V. Terekhova

引用次数: 0

摘要

首次使用原生、改性和聚合环糊精来提高合成免疫调节剂芬戈莫德（FTY720）的溶解度和生物利用度。研究表明，FTY720 的溶解度在环糊精的存在下会增加。根据实验得到的 FTY720 相溶解度图，计算出了客主复合物的稳定性常数和环糊精增溶作用的效率指数。研究还考虑了环糊精结构对 FTY720 增溶作用的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Solubilization of the New Generation Immunomodulator Fingolimod Using Natural, Modified, and Polymeric Cyclodextrins

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Solubilization of the New Generation Immunomodulator Fingolimod Using Natural, Modified, and Polymeric Cyclodextrins

Native, modified, and polymeric cyclodextrins are used for the first time to improve the solubility and bioavailability of synthetic immunomodulator fingolimod (FTY720). It is shown that the solubility of FTY720 grows in the presence of cyclodextrins. Constants of the stability of guest–host complexes and the index of efficiency of the solubilizing action of cyclodextrins are calculated from experimentally obtained phase solubility diagrams of FTY720. The effect the structure of cyclodextrin on the solubilization of FTY720 is considered.

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来源期刊

Russian Journal of Physical Chemistry A 化学-物理化学

CiteScore

1.20

自引率

14.30%

发文量

376

审稿时长

5.1 months

期刊介绍： Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world. Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.