线粒体琥珀酸盐在癌症中促进T细胞衰竭

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-02-10 DOI:10.1016/j.ccell.2025.01.005

Lorenzo Galluzzi, Emma Guilbaud, Abhishek D. Garg

引用次数: 0

摘要

线粒体适应性对于CD8+ T细胞对抗癌症的反应至关重要。在这一期的《癌细胞》杂志上，Ma等人描述了一种新的机制，将脯氨酸4-羟化酶亚基α 1 （P4HA1）引发的线粒体代谢缺陷与T细胞衰竭和肿瘤对免疫治疗敏感性降低联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitochondrial succinate feeds T cell exhaustion in cancer

Mitochondrial fitness is critical for effector CD8⁺ T cell responses against cancer. In this issue of Cancer Cell, Ma et al. delineate a novel mechanism linking defects in mitochondrial metabolism as elicited by prolyl 4-hydroxylase subunit alpha 1 (P4HA1) to T cell exhaustion and reduced tumor sensitivity to immunotherapy.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.