喉肌诱发电位记录用于实验性迷走神经刺激。

Q1 Health Professions
Helen Bachmann, Robrecht Raedt, Guy Laureys, Kristl Vonck
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引用次数: 0

摘要

喉肌诱发电位(LMEP)是迷走神经刺激(VNS)实验中保证神经电极界面完整性的神经生理学结果参数。本文讨论了46只雌性Lewis大鼠在左侧颈迷走神经周围植入定制的VNS电极后的大量微创LMEP记录。恢复3周后,每只动物记录两次lmep,交换VNS电极的阳极和阴极位置(极性反转)。vns诱发的LMEP被确定为刺激后的初始负峰波伪影,在给定的刺激输出电流下的所有扫描中都一致记录。潜伏期定义为从刺激开始到这个负峰的时间,刺激阈值定义为显示清晰且可重复的LMEP的最低电流。46只动物中有37只(80.4%)出现LMEP反应,刺激强度阈值为0.37±0.27 mA,潜伏期为2.39±0.45 ms。在尾部电极接触处首先施加阴极脉冲相位导致LMEP潜伏期最短(MWU: p = 0.049)。(2.36±0.43 ms vs. 2.41±0.47 ms)。微创LMEP记录为检查电极功能和正确植入提供了可行可靠的手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation

Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation

The laryngeal muscle evoked potential (LMEP) is a neurophysiological outcome parameter that guarantees integrity of the nerve-electrode interface during experiments with vagus nerve stimulation (VNS). This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats, implanted with a custom-made VNS electrode around the left cervical vagus nerve. After a 3-week recovery, LMEPs were recorded twice in each animal, with swapping the anode and cathode positions of the VNS electrode (polarity inversion). A VNS-induced LMEP was identified as the initial negative peak wave post-stimulation artifact, consistently recorded in all sweeps at a given stimulation output current. Latency was defined as the time from stimulation onset to this negative peak, and stimulation threshold as the lowest current showing a clear and reproducible LMEP. An LMEP response was shown by 37/46 animals (80.4%), with stimulation intensity threshold of 0.37 ± 0.27 mA and latency of 2.39 ± 0.45 ms. Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies (MWU: p = 0.049. 2.36 ± 0.43 ms vs. 2.41 ± 0.47 ms). Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.

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来源期刊
CiteScore
5.50
自引率
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审稿时长
12 weeks
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