Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Susan Mikkelsen, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Khoa Manh Dinh, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Janna Nissen, Thorsten Brodersen, Mikkel Steen Petersen, Klaus Rostgaard, Henrik Hjalgrim, Erik Sørensen, Sisse Rye Ostrowski, Ole Birger Pedersen, Christian Lodberg Hvas, Christian Erikstrup
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引用次数: 0
摘要
目的：了解健康献血者的胃肠道症状和排便习惯，探讨症状表型及其相关因素。方法：在2020年11月至2023年3月期间，53046名丹麦献血者研究的参与者完成了一份调查问卷，包括13种胃肠道症状、排便模式规律、大便频率和大便一致性。我们使用数据驱动的方法来探索症状表型，并通过多项逻辑回归研究相关因素。结果：在53046名参与者（52%为女性）中，68% （95% CI 67.5%至68.3%）报告了13种胃肠道症状中的至少一种。最常见的症状是腹胀（40%）、腹部隆隆声（40%）、腹痛（17%）、反酸（13%）、胃灼热（12%）、腹泻（12%）、恶心（12%）和便秘（10%）。一半的参与者（50%）有规律的排便模式（定义为粪便一致性和排便频率大致相同），包括布里斯托尔粪便量表4每天大便1-3次。51 820例近完整病例参与者的症状表型及其患病率如下：(1)无胃肠道症状（32%）；(2)仅肿胀和/或隆隆声（21%）；(3)仅反酸和/或烧心（4%）；(4)任何其他一种或两种症状（14%）；(5)出现三种或四种症状（18%）；(6)任何五种或六种症状（7%）；(7)至少有7种症状（3%）。只有反酸和/或胃灼热的表型与肥胖相关，其余的症状表型与女性、年龄下降和不规则排便模式相关，即使排除了自我报告的肠易激综合征、乳糖不耐受或麸质不耐受的个体。结论：大多数健康成年人，尤其是50岁以下的女性，都会出现胃肠道症状。症状表型与性别、年龄和排便习惯密切相关。
Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study.
Objective: To characterise gastrointestinal symptoms and bowel habits in healthy blood donors and explore symptom phenotypes and their associated factors.
Methods: Between November 2020 and March 2023, 53 046 participants in the nationwide Danish Blood Donor Study completed a questionnaire including 13 gastrointestinal symptoms, defaecation pattern regularity, stool frequency, and stool consistency. We used a data-driven approach to explore symptom phenotypes and investigated associated factors by multinomial logistic regression.
Results: Among the 53 046 participants (52% women), 68% (95% CI 67.5% to 68.3%) reported at least one of 13 gastrointestinal symptoms. The most frequent symptoms were bloating (40%), abdominal rumbling (40%), abdominal pain (17%), acid regurgitation (13%), heartburn (12%), diarrhoea (12%), nausea (12%), and constipation (10%). Half of the participants (50%) had a regular defaecation pattern (defined as generally the same stool consistency and stool frequency) consisting of Bristol Stool Form Scale 4 stools 1-3 times per day. Symptom phenotypes and their prevalence among 51 820 near-complete case participants were as follows: (1) no gastrointestinal symptoms (32%); (2) bloating and/or rumbling only (21%); (3) acid regurgitation and/or heartburn only (4%); (4) any other one or two symptoms (14%); (5) any three or four symptoms (18%); (6) any five or six symptoms (7%); (7) at least seven symptoms (3%). The acid regurgitation and/or heartburn only phenotype associated with obesity, and the remaining symptomatic phenotypes were associated with female sex, decreasing age, and an irregular defaecation pattern, even after excluding individuals with self-reported irritable bowel syndrome, lactose intolerance, or gluten intolerance.
Conclusion: Most healthy adults, especially women younger than 50 years, experience gastrointestinal symptoms. Symptom phenotypes strongly correlate with sex, age, and bowel habits.
期刊介绍：
BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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