{"title":"揭示MRSA抗生素耐药性：环境、污染和医疗质量的影响——在中国的全国性探索：2014年至2021年中国大陆的综合分析","authors":"Yi-Chang Zhao, Ming-Xuan Xiao, Zhi-Hua Sun, Jia-Kai Li, Huai-yuan Liu, Bi-Kui Zhang, Hua-Lin Cai, Wei Cao, Feng Yu, Miao Yan","doi":"10.1186/s12302-025-01064-2","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. Among resistant pathogens, methicillin-resistant <i>Staphylococcus</i> <i>aureus</i> (MRSA) poses a particularly severe and expanding threat. However, there is a lack of comprehensive studies on the prevalence, patterns, and contributing factors of MRSA resistance within mainland China.</p><h3>Methods</h3><p>In this study, the data of MRSA antimicrobial resistance in 31 provinces from 2014 to 2021 were obtained from the China Antimicrobial Resistance Surveillance System (CARSS). Environment and medical care data were obtained either from the National Bureau of Statistics (NBS) database or the National Ministry of Ecology and Environment (NMEE). Multiple linear regression and restricted cubic spline (RCS) was used to explore the potential influencing factors of MRSA antibiotic resistance rate (AMR).</p><h3>Results</h3><p>Significant positive associations were identified between MRSA AMR and various factors, including cadmium pollution, soybean and poultry production, and oil consumption. Conversely, an inverse J-shaped relationship was observed between tap water coverage and MRSA resistance. Other noteworthy correlations included the effects of corn and pork production, as well as antibiotic use intensity. Our predictive model explained 52.7% of the variability in MRSA AMR, demonstrating strong predictive capability.</p><h3>Conclusions</h3><p>This study highlights the significant role of environmental, agricultural, and healthcare factors in influencing MRSA AMR in China. The findings emphasize the need for integrated strategies addressing regional environmental and healthcare quality in combating antibiotic resistance. Extending this research globally could enhance understanding of MRSA resistance dynamics on a broader scale.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"37 1","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s12302-025-01064-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021 in mainland China\",\"authors\":\"Yi-Chang Zhao, Ming-Xuan Xiao, Zhi-Hua Sun, Jia-Kai Li, Huai-yuan Liu, Bi-Kui Zhang, Hua-Lin Cai, Wei Cao, Feng Yu, Miao Yan\",\"doi\":\"10.1186/s12302-025-01064-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. Among resistant pathogens, methicillin-resistant <i>Staphylococcus</i> <i>aureus</i> (MRSA) poses a particularly severe and expanding threat. However, there is a lack of comprehensive studies on the prevalence, patterns, and contributing factors of MRSA resistance within mainland China.</p><h3>Methods</h3><p>In this study, the data of MRSA antimicrobial resistance in 31 provinces from 2014 to 2021 were obtained from the China Antimicrobial Resistance Surveillance System (CARSS). Environment and medical care data were obtained either from the National Bureau of Statistics (NBS) database or the National Ministry of Ecology and Environment (NMEE). Multiple linear regression and restricted cubic spline (RCS) was used to explore the potential influencing factors of MRSA antibiotic resistance rate (AMR).</p><h3>Results</h3><p>Significant positive associations were identified between MRSA AMR and various factors, including cadmium pollution, soybean and poultry production, and oil consumption. Conversely, an inverse J-shaped relationship was observed between tap water coverage and MRSA resistance. Other noteworthy correlations included the effects of corn and pork production, as well as antibiotic use intensity. Our predictive model explained 52.7% of the variability in MRSA AMR, demonstrating strong predictive capability.</p><h3>Conclusions</h3><p>This study highlights the significant role of environmental, agricultural, and healthcare factors in influencing MRSA AMR in China. The findings emphasize the need for integrated strategies addressing regional environmental and healthcare quality in combating antibiotic resistance. Extending this research globally could enhance understanding of MRSA resistance dynamics on a broader scale.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":546,\"journal\":{\"name\":\"Environmental Sciences Europe\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2025-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1186/s12302-025-01064-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Sciences Europe\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s12302-025-01064-2\",\"RegionNum\":3,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Sciences Europe","FirstCategoryId":"93","ListUrlMain":"https://link.springer.com/article/10.1186/s12302-025-01064-2","RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Unmasking MRSA antibiotic resistance: the impact of environment, pollution, and healthcare quality—a nationwide exploration in China: a comprehensive analysis spanning 2014 to 2021 in mainland China
Background
The rise of antibiotic resistance has become a critical global health concern, resulting in numerous fatalities annually. Among resistant pathogens, methicillin-resistant Staphylococcusaureus (MRSA) poses a particularly severe and expanding threat. However, there is a lack of comprehensive studies on the prevalence, patterns, and contributing factors of MRSA resistance within mainland China.
Methods
In this study, the data of MRSA antimicrobial resistance in 31 provinces from 2014 to 2021 were obtained from the China Antimicrobial Resistance Surveillance System (CARSS). Environment and medical care data were obtained either from the National Bureau of Statistics (NBS) database or the National Ministry of Ecology and Environment (NMEE). Multiple linear regression and restricted cubic spline (RCS) was used to explore the potential influencing factors of MRSA antibiotic resistance rate (AMR).
Results
Significant positive associations were identified between MRSA AMR and various factors, including cadmium pollution, soybean and poultry production, and oil consumption. Conversely, an inverse J-shaped relationship was observed between tap water coverage and MRSA resistance. Other noteworthy correlations included the effects of corn and pork production, as well as antibiotic use intensity. Our predictive model explained 52.7% of the variability in MRSA AMR, demonstrating strong predictive capability.
Conclusions
This study highlights the significant role of environmental, agricultural, and healthcare factors in influencing MRSA AMR in China. The findings emphasize the need for integrated strategies addressing regional environmental and healthcare quality in combating antibiotic resistance. Extending this research globally could enhance understanding of MRSA resistance dynamics on a broader scale.
期刊介绍：
ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation.
ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation.
ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation.
Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues.
Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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