一种新的卵巢癌迁移、侵袭和粘附调节因子。

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell and Bioscience Pub Date : 2025-02-06 DOI:10.1186/s13578-025-01349-2

Lanning Bai, Xueqian Qian, Hui Zhang, Yi Yuan, Xiaodong Cui, Min Cheng, Yangyang Han

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引用次数: 0

摘要

背景：卵巢癌（OC）是最常见的妇科恶性肿瘤之一，在所有妇科恶性肿瘤中死亡率最高。缺乏早期诊断生物标志物和治疗靶点导致总体5年生存率在30%至50%之间。Plectin （PLEC）是一种500 kDa的支架蛋白，近年来因其在细胞形态学、迁移和粘附等多种细胞生物学功能中的关键作用而受到关注，但PLEC在OC中的确切作用尚不清楚。结果：在本研究中，我们的研究结果表明PLEC在体外和体内对OC的进展有积极的影响，包括细胞增殖、迁移、侵袭和粘附。结论：本研究结果为卵巢癌的诊断和治疗提供了新的思路。

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Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer.

Background: Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeutic target contributes to an overall 5-year survival rate ranging from 30 to 50%. Plectin (PLEC), a 500 kDa scaffolding protein, has gained prominence in recent years due to its pivotal role in various cellular biological functions such as cell morphology, migration and adhesion, while the accurate role of PLEC in OC remains elusive.

Results: In this study, our findings demonstrate that PLEC exerts a positive influence on the progression of OC, encompassing cellular proliferation, migration, invasion, and adhesion both in vitro and in vivo.

Conclusions: The results providing new insights for the diagnosis and treatment in OC.

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来源期刊

Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

10.70

自引率

0.00%

发文量

187

审稿时长

>12 weeks

期刊介绍： Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.