万古霉素在分娩后脐带血中的浓度。

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Obstetrics and gynecology Pub Date : 2025-04-01 Epub Date: 2025-02-06 DOI:10.1097/AOG.0000000000005843

Sarah A Coggins, Kelly C Wade, Kevin M Watt, Kevin J Downes, Karen M Puopolo

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引用次数: 0

摘要

关于母体给药的胎儿-新生儿药代动力学，体重为基础的万古霉素剂量为B群链球菌（GBS）产时抗生素预防所知甚少。我们的目的是量化产妇分娩时体重为基础给药万古霉素后脐带血万古霉素浓度，并评估脐带血万古霉素水平与既定的GBS临床最低抑制浓度（MIC）断点的关系。使用从我们的生物库中提取的方便的血清样本，我们测量了26名产妇在分娩时暴露于万古霉素后脐带血中的万古霉素水平。大多数新生儿(24/26,92.3%；95% CI, 74.9-99.1%)，万古霉素脐带血水平高于GBS的MIC临界点（1微克/毫升或更高）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vancomycin Concentrations in Umbilical Cord Blood After Intrapartum Exposure.

Little is known about the fetal-neonatal pharmacokinetics of maternally administered, weight-based vancomycin dosing for group B streptococcus (GBS) intrapartum antibiotic prophylaxis. Our objective was to quantify vancomycin concentrations in umbilical cord blood at birth after weight-based maternal intrapartum vancomycin administration and to assess cord blood vancomycin levels relative to the established GBS clinical minimum inhibitory concentration (MIC) breakpoint. Using a convenience sample of stored sera from our biorepository, we measured vancomycin levels in umbilical cord blood from 26 neonates after maternal intrapartum vancomycin exposure. Most neonates (24/26, 92.3%; 95% CI, 74.9-99.1%) had vancomycin cord blood levels above the MIC breakpoint (1 microgram/mL or higher) for GBS.

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来源期刊

Obstetrics and gynecology 医学-妇产科学

CiteScore

11.10

自引率

4.20%

发文量

867

审稿时长

1 months

期刊介绍： "Obstetrics & Gynecology," affectionately known as "The Green Journal," is the official publication of the American College of Obstetricians and Gynecologists (ACOG). Since its inception in 1953, the journal has been dedicated to advancing the clinical practice of obstetrics and gynecology, as well as related fields. The journal's mission is to promote excellence in these areas by publishing a diverse range of articles that cover translational and clinical topics. "Obstetrics & Gynecology" provides a platform for the dissemination of evidence-based research, clinical guidelines, and expert opinions that are essential for the continuous improvement of women's health care. The journal's content is designed to inform and educate obstetricians, gynecologists, and other healthcare professionals, ensuring that they stay abreast of the latest developments and best practices in their field.