用靶向税收的树突状细胞疫苗消除残留的成人t细胞白血病克隆

EJHaem Pub Date : 2025-02-06 DOI:10.1002/jha2.1072

Tadafumi Iino, Atsuhiko Hasegawa, Takaji Matsutani, Koichi Akashi, Mari Kannagi, Youko Suehiro

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引用次数: 0

摘要

一项针对成人t细胞白血病/淋巴瘤（ATL）的Tax肽脉冲树突状细胞（DC）疫苗的初步临床研究显示出良好的临床结果。方法：通过T细胞受体（TCR）库分析，研究了一名ATL患者接种DC疫苗后10年完全缓解的样本的抗肿瘤作用。结果在该患者中，接种DC疫苗后3年内，先前治疗后持续存在的显性残余ATL克隆完全消失。此外，DC疫苗恢复了正常T细胞和新诱导的功能性税收特异性CD8+ T细胞克隆的TCR库多样性。结论DC疫苗介导的正常T细胞免疫的恢复可能有助于这种持久的缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Elimination of residual adult T-cell leukaemia clones by Tax-targeted dendritic cell vaccine

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Elimination of residual adult T-cell leukaemia clones by Tax-targeted dendritic cell vaccine

Background

A pilot clinical study of a Tax peptide-pulsed dendritic cell (DC) vaccine for adult T-cell leukaemia/lymphoma (ATL) indicated favourable clinical outcomes.

Methods

We investigated its anti-tumour effect by T cell receptor (TCR) repertoire analysis in samples from an enrolled ATL patient who achieved a 10-year complete remission after DC vaccination.

Results

In this patient, the dominant residual ATL clones that had persisted following previous treatment entirely disappeared within 3 years after DC vaccination. Additionally, the DC vaccine restored TCR repertoire diversity of normal T cells and newly induced functional Tax-specific CD8⁺ T cell clones.

Conclusions

The recovery of normal T cell immunity mediated by the DC vaccine may contribute to this long-lasting remission.

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来源期刊

EJHaem

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