超声辅助伊沙廷、丙二腈和 β-酮酯的级联缩合：具有预期抗食管癌活性的新型螺吲哚衍生物的高效一锅合成方法

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-02-06 DOI:10.1134/S1070428024120236

Gh. S. Yaqoob, A. M. Jassem, A. M. Dhumad, H. A. S. Jabir

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引用次数: 0

摘要

本文报道了在三乙胺存在下，以异丙二腈、异丙二腈和各种β-酮酯为原料，在超声照射下，通过三组分反应，绿色、简便地一锅合成了新型氧化螺[吲哚-3,4 ' -吡喃]衍生物。该工艺具有方法简单、收率高、反应干净、原子经济性高、反应时间短、环境友好等生态效益。对合成的螺菌吲哚衍生物进行分子对接，评价其抗食管癌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ultrasound-Assisted Cascade Condensation of Isatin, Malononitrile, and β-Keto Esters: An Efficient One-Pot Synthesis of Novel Spirooxindole Derivatives with Expected Anti-Esophageal Cancer Activity

查看原文本刊更多论文

Ultrasound-Assisted Cascade Condensation of Isatin, Malononitrile, and β-Keto Esters: An Efficient One-Pot Synthesis of Novel Spirooxindole Derivatives with Expected Anti-Esophageal Cancer Activity

A green and facile one-pot synthesis of novel oxospiro[indole-3,4′-pyran] derivatives via a three-component reaction of isatin, malononitrile, and various β-keto esters in the presence of triethylamine under ultrasonic irradiation is reported. This protocol offers several ecological benefits including simple methodology, good to excellent yields, clean reaction, higher atom economy, shorter reaction time, and environmental friendliness. Molecular docking of the synthesized spirooxindole derivatives was performed to evaluate their anti-esophageal cancer activity.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.