可见光诱导羧酸与芳基磺酸盐的酯化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-26 DOI:10.1021/acs.orglett.4c0475510.1021/acs.orglett.4c04755

Fang Xia, and , Cheng-Pan Zhang*,

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引用次数: 0

摘要

为了方便地合成邻芳基酯，本文描述了光诱导铜介导的芳基噻吩或芳基苯氧磷盐与脂肪或芳香羧酸的酰基化反应。该反应具有效率高、官能团耐受性好、化学选择性好、能酯化复杂药物分子等明显的优势，为合成多官能团和立体拥塞的邻芳基酯提供了一条实用的途径，在开发新的前药或双生药方面具有潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Induced Esterification of Carboxylic Acids with Arylsulfonium Salts

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Visible-Light-Induced Esterification of Carboxylic Acids with Arylsulfonium Salts

A photoinduced copper-mediated acyloxylation of arylthianthrenium or arylphenoxathiinium salts with either aliphatic or aromatic carboxylic acids is described for the convenient synthesis of O-aryl esters. The reaction has shown obvious advantages, such as high efficiency, good functional group tolerance, excellent chemoselectivity, and capacity for esterification of complex drug molecules, offering a practical synthetic route to multifunctionalized and sterically congested O-aryl esters, which are potentially useful in the development of new prodrugs or twin drugs.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.