在多肽和蛋白质合成上的发光：发光二极管驱动半胱氨酸脱硫生成丙氨酸的孟加拉玫瑰

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-23 DOI:10.1021/acs.orglett.4c0467110.1021/acs.orglett.4c04671

Mateusz Waliczek*, and , Piotr Stefanowicz,

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引用次数: 0

摘要

研究提出可见光诱导脱硫肽含有半胱氨酸残基已进行。这种由发光二极管型光驱动的转化在室温下的水溶液中以高效率进行，并涉及到使用催化量的光敏剂Rose Bengal。该方法已在模型合成肽、溶菌酶C和α-晶体蛋白上进行了测试，并成功应用于一锅天然化学连接（NCL）脱硫方案。

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Shining a Light on Peptide and Protein Synthesis: Light-Emitting-Diode-Driven Desulfurization of Cysteine to Alanine with Rose Bengal

Studies presenting visible-light-induced desulfurization of peptides containing a cysteine residue have been carried out. This transformation driven by light-emitting-diode-type light proceeds with high efficiency in an aqueous solution at room temperature and involves the use of a catalytic amount of photosensitizer, Rose Bengal. The procedure has been tested on model synthetic peptides, lysozyme C and α-crystallin, and successfully applied to a one-pot native chemical ligation (NCL)–desulfurization protocol.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.