在糖尿病前期个体中，Lp(a)浓度和多态性大小与新发糖尿病无关。

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2025-02-03 DOI:10.1016/j.diabet.2025.101621

Maxime Carpentier , Matthieu Wargny , Mikaël Croyal , Cédric Le May , Sarra Smati , Edith Bigot-Corbel , Samy Hadjadj , Bertrand Cariou

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引用次数: 0

摘要

目的：在普通人群中的观察性研究表明，低浓度脂蛋白(a) [Lp(a)]与2型糖尿病的风险增加有关。在这里，我们的目的是确定Lp(a)血浆浓度和Kringle-IV （K-IV）重复多态性是否与糖尿病前期个体的新发糖尿病（NOD）相关。方法：IT-DIAB是一项观察性前瞻性研究，包括303名空腹血糖受损（空腹血糖[FPG]: 110-125 mg/dl）的参与者，每年随访5年。主要终点是NOD的发展，定义为随访期间首次FPG值≥126 mg/dl。免疫比浊法测定Lp(a)浓度，质谱法测定载脂蛋白(a)浓度和K-IV结构域数量。在Lp(a)或K-IV阈值二值化后，使用Kaplan-Meier曲线和多变量Cox模型对NOD的生存分析进行建模。结果：在参与者中，113例（37%）在随访期间发生NOD。不同NOD状态下Lp(a)的浓度和K-IV结构域的数量无显著差异。同样，在有或没有NOD的患者中，Lp(a)浓度不可检测（≤7 nmol/l）或升高（>125 nmol/l）的患者比例相似：分别为68.1 vs 63.7% （P = 0.46）和8.8 vs 8.9% （P > 0.99）。Kaplan-Meier曲线和Cox模型未显示Lp(a)浓度（阈值为7 nmol/l和125 nmol/l）或K-IV结构域数量（阈值为23）与NOD风险之间存在任何关联。结论：在高危人群中，Lp(a)浓度或多态性大小似乎与2型糖尿病风险无关。

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Lp(a) concentration and polymorphic size are not associated with new onset diabetes in individuals with prediabetes

Aim

Observational studies in the general population suggest that low concentrations of lipoprotein (a) [Lp(a)] are associated with an increased risk of type 2 diabetes. Here, we aim to determine whether Lp(a) plasma concentration and Kringle-IV (K-IV) repeat polymorphism were associated with new-onset diabetes (NOD) in individuals with prediabetes.

Methods

IT-DIAB is an observational, prospective study including 303 participants with impaired fasting glucose (fasting plasma glucose [FPG]: 110–125 mg/dl) followed annually for 5 years. The primary endpoint was the development of NOD, defined as a first FPG value ≥ 126 mg/dl during follow-up. Lp(a) concentrations were measured by immunoturbidimetry, apo(a) concentrations and the number of K-IV domains by mass spectrometry. Survival analyses for NOD were modeled using Kaplan-Meier curves and a multivariable Cox model, after binarization on threshold values of Lp(a) or K-IV.

Results

Among the participants, 113 (37%) developed NOD during follow-up. The concentrations of Lp(a) and the number of K-IV domains were not significantly different according to NOD status. Similarly, the percentage of patients with a non-detectable (≤ 7 nmol/l) or elevated (>125 nmol/l) Lp(a) concentration was similar between those with or without NOD: 68.1 vs 63.7% (P = 0.46) and 8.8 vs 8.9% (P > 0.99), respectively. Kaplan-Meier curves and Cox models did not show any association between Lp(a) concentration (threshold 7 nmol/l and 125 nmol/l) or number of K-IV domain (threshold 23) and the risk of NOD.

Conclusion

In a high-risk population, Lp(a) concentration or polymorphic size do not appear to be substantially associated with type 2 diabetes risk.

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来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.