对线虫感染的保护可能是由先天防御而不是它们的微生物群介导的。

IF 3.7 2区 医学 Q1 PARASITOLOGY
Chava L. Weitzman , Gregory P. Brown , Kimberley Day , Catherine M. Shilton , Karen Gibb , Keith Christian
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引用次数: 0

摘要

宿主相关微生物组通过与入侵者的直接和间接相互作用,在多种系统中提供对疾病的保护,尽管这些相互作用在野生动物非肠道蠕虫感染的背景下鲜为人知。在这里,我们使用广泛的侵入性宿主-寄生虫系统来更好地了解蠕虫-两栖动物-微生物组动力学。本研究以蔗蜍及其寄生的肺虫为研究对象,研究肺虫感染丰度与皮肤和肠道(结肠)细菌微生物群的相互作用。通过两个实验,第一个减少皮肤细菌负荷,第二个减少细菌多样性,我们没有发现皮肤细菌保护免受感染的证据。我们也没有发现依赖于肺虫感染的不同肠道群落,这表明感染引起肠道群落变化的免疫调节很少或没有,至少在最初的寄生虫暴露后的第一个月。根据之前在该系统中的工作,这些结果强调了蟾蜍的先天易感性(包括皮肤分泌物可能提供的保护)而不是皮肤微生物在决定这些大型寄生虫感染几率方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protection against anuran lungworm infection may be mediated by innate defenses rather than their microbiome
Host-associated microbiomes provide protection against disease in diverse systems, through both direct and indirect interactions with invaders, although these interactions are less understood in the context of non-gut helminth infections in wildlife. Here, we used a widespread, invasive host–parasite system to better understand helminth–amphibian–microbiome dynamics. We focus on cane toads and their lungworm parasites, which invade the host through the skin, to study the interactions between lungworm infection abundance and skin and gut (colon) bacterial microbiomes. Through two experiments, first reducing skin bacterial loads, and second reducing bacterial diversity, we found no evidence of protection by skin bacteria against infection. We also did not find divergent gut communities dependent on lungworm infection, signifying little to no immune modulation from infection causing changes to gut communities, at least in the first month after initial parasite exposure. In light of previous work in the system, these results underscore the contribution of toads’ innate susceptibility (including possible protection provided by skin secretions) rather than skin microbes in determining the chance of infection by these macroparasites.
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来源期刊
CiteScore
8.40
自引率
2.50%
发文量
76
审稿时长
23 days
期刊介绍: International Journal for Parasitology offers authors the option to sponsor nonsubscriber access to their articles on Elsevier electronic publishing platforms. For more information please view our Sponsored Articles page. The International Journal for Parasitology publishes the results of original research in all aspects of basic and applied parasitology, including all the fields covered by its Specialist Editors, and ranging from parasites and host-parasite relationships of intrinsic biological interest to those of social and economic importance in human and veterinary medicine and agriculture.
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