评估阿片类药物快速反应系统预防过量死亡的国家随机对照试验方案。

IF 2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2025-02-03 DOI:10.1016/j.cct.2025.107835

Dametreea L. Carr , Michael L. Hecht , Michelle N. Shiota , Mohan Zalake , Janice Krieger , Hye Jeong Choi

{"title":"评估阿片类药物快速反应系统预防过量死亡的国家随机对照试验方案。","authors":"Dametreea L. Carr , Michael L. Hecht , Michelle N. Shiota , Mohan Zalake , Janice Krieger , Hye Jeong Choi","doi":"10.1016/j.cct.2025.107835","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Deaths of opioid overdose are a serious public health concern throughout the U.S., transcending geographical and demographic categories. While naloxone can reverse an overdose and prevent death, it must be administered in a timely fashion. Efforts to get naloxone widely distributed contribute to harm reduction efforts, but more efficient strategies for recruiting people to carry and administer naloxone will increase the impact and advance prevention science. Yet, most existing programs are not evidence-based. The Opioid Rapid Response System (ORRS) was developed for these purposes.</div></div><div><h3>Methods</h3><div>A randomized controlled trial will be conducted in 9 communities in Pennsylvania, Arizona, and Washington to evaluate ORRS. The RCT will be conducted with pretest and posttest surveys administered to assess the effectiveness of the training. Focus groups will inform the development of the ORRS training. To increase the appeal of naloxone training for volunteers, recruitment strategies will focus on personal and social identity.</div></div><div><h3>Conclusion</h3><div>The Opioid Rapid Response System is a theory-driven program that recruits and trains lay citizens to respond to opioid overdose events. The program has the potential to advance knowledge of lay citizen recruitment and training, and to reduce deaths from overdoses.</div><div><strong><em>Trial registration</em></strong>: <span><span>NCT06238128</span><svg><path></path></svg></span></div></div>","PeriodicalId":10636,"journal":{"name":"Contemporary clinical trials","volume":"150 ","pages":"Article 107835"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protocol for a national randomized controlled trial evaluating the Opioid Rapid Response System for overdose death prevention\",\"authors\":\"Dametreea L. Carr , Michael L. Hecht , Michelle N. Shiota , Mohan Zalake , Janice Krieger , Hye Jeong Choi\",\"doi\":\"10.1016/j.cct.2025.107835\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Deaths of opioid overdose are a serious public health concern throughout the U.S., transcending geographical and demographic categories. While naloxone can reverse an overdose and prevent death, it must be administered in a timely fashion. Efforts to get naloxone widely distributed contribute to harm reduction efforts, but more efficient strategies for recruiting people to carry and administer naloxone will increase the impact and advance prevention science. Yet, most existing programs are not evidence-based. The Opioid Rapid Response System (ORRS) was developed for these purposes.</div></div><div><h3>Methods</h3><div>A randomized controlled trial will be conducted in 9 communities in Pennsylvania, Arizona, and Washington to evaluate ORRS. The RCT will be conducted with pretest and posttest surveys administered to assess the effectiveness of the training. Focus groups will inform the development of the ORRS training. To increase the appeal of naloxone training for volunteers, recruitment strategies will focus on personal and social identity.</div></div><div><h3>Conclusion</h3><div>The Opioid Rapid Response System is a theory-driven program that recruits and trains lay citizens to respond to opioid overdose events. The program has the potential to advance knowledge of lay citizen recruitment and training, and to reduce deaths from overdoses.</div><div><strong><em>Trial registration</em></strong>: <span><span>NCT06238128</span><svg><path></path></svg></span></div></div>\",\"PeriodicalId\":10636,\"journal\":{\"name\":\"Contemporary clinical trials\",\"volume\":\"150 \",\"pages\":\"Article 107835\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-02-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contemporary clinical trials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1551714425000291\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary clinical trials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1551714425000291","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

导言：阿片类药物过量死亡是整个美国严重的公共卫生问题，超越了地理和人口类别。虽然纳洛酮可以逆转过量服用并防止死亡，但必须及时给药。广泛分发纳洛酮有助于减少危害，但招募人员携带和使用纳洛酮的更有效策略将增加影响并推进预防科学。然而，大多数现有的项目都没有证据。阿片类药物快速反应系统（ORRS）就是为此目的而开发的。方法：在宾夕法尼亚州、亚利桑那州和华盛顿州的9个社区进行随机对照试验，对ORRS进行评估。随机对照试验将在测试前和测试后进行调查，以评估培训的有效性。焦点小组将为职业康复培训的发展提供信息。为了增加纳洛酮培训对志愿者的吸引力，招聘策略将侧重于个人和社会认同。结论：阿片类药物快速反应系统是一个理论驱动的计划，招募和培训非专业公民应对阿片类药物过量事件。该计划有可能提高对普通公民招募和培训的了解，并减少过量用药造成的死亡。试验注册：NCT06238128。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Protocol for a national randomized controlled trial evaluating the Opioid Rapid Response System for overdose death prevention

Introduction

Deaths of opioid overdose are a serious public health concern throughout the U.S., transcending geographical and demographic categories. While naloxone can reverse an overdose and prevent death, it must be administered in a timely fashion. Efforts to get naloxone widely distributed contribute to harm reduction efforts, but more efficient strategies for recruiting people to carry and administer naloxone will increase the impact and advance prevention science. Yet, most existing programs are not evidence-based. The Opioid Rapid Response System (ORRS) was developed for these purposes.

Methods

A randomized controlled trial will be conducted in 9 communities in Pennsylvania, Arizona, and Washington to evaluate ORRS. The RCT will be conducted with pretest and posttest surveys administered to assess the effectiveness of the training. Focus groups will inform the development of the ORRS training. To increase the appeal of naloxone training for volunteers, recruitment strategies will focus on personal and social identity.

Conclusion

The Opioid Rapid Response System is a theory-driven program that recruits and trains lay citizens to respond to opioid overdose events. The program has the potential to advance knowledge of lay citizen recruitment and training, and to reduce deaths from overdoses.

Trial registration: NCT06238128

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.