利用缬氨酸限制诱导的 DNA 损伤进行癌症靶向治疗

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-02-06 DOI:10.1016/j.molcel.2025.01.005

Alma Sophia Barisaac, Enas R. Abu-Zhayia, Nabieh Ayoub

引用次数: 0

摘要

代谢物微环境塑造了癌症治疗策略。在最近发表于《自然》（Nature）的一篇论文中，Jin 等人1 证明，缬氨酸缺乏会触发 HDAC6 进入细胞核，导致 DNA 损伤积累，从而可用于癌症靶向治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.¹ demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.