日本第12版与美国癌症联合委员会第8版胸内食管鳞状细胞癌分类的比较与验证

IF 2.2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Esophagus Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI:10.1007/s10388-025-01111-0
Seyeon Jeon, Boram Park, Seong Yong Park, Yeong Jeong Jeon, Junghee Lee, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Young Mog Shim
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引用次数: 0

摘要

背景:食管癌分期可采用美国癌症联合委员会(AJCC)第8版和日本分类第12版。本回顾性研究旨在比较这两种分期系统在手术治疗食管鳞状细胞癌(ESCC)患者中的应用。方法:回顾性分析1994年至2020年2853例食道切除术和淋巴结切除术患者的资料。患者分为前期治疗组(n = 2156)和新辅助治疗组(n = 697)。结果:患者平均年龄63.5±8.2岁,中位随访时间7.6年。比较两种分期系统表明,患者更有可能被日本分类法分期较低。在两种分期系统中,前期组的总生存期(OS)和无病生存期的生存曲线被很好地分离(p结论:AJCC第8版和日本分类第12版预测了接受前期手术患者的生存,而两种分期系统都显示了接受新辅助治疗患者的生存曲线交叉。对于接受新辅助治疗和手术的ESCC患者,需要更准确的分期系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison and validation of the Japanese classification 12th edition and American joint committee on cancer 8th edition on intrathoracic esophageal squamous cell carcinoma.

Background: The American Joint Committee on Cancer (AJCC) 8th edition and Japanese classification 12th edition can be applied for esophageal cancer staging. This retrospective study aimed to compare these two staging systems in patients with surgically treated esophageal squamous cell carcinoma (ESCC).

Methods: We retrospectively reviewed 2,853 patients who underwent esophagectomy and lymphadenectomy from 1994 to 2020. Patients were divided into the upfront (n = 2156) and neoadjuvant (n = 697) groups.

Results: The mean age of the patients was 63.5 ± 8.2 years with a median follow-up of 7.6 years. Comparing both staging systems showed that patients were more likely to be staged lower by the Japanese classification. Survival curves for overall survival (OS) and disease-free survival in the upfront group were well separated in the two staging systems (p < 0.01), and the HR for survival significantly increased as the stage increased. In the neoadjuvant group, there were crossovers of survival curves between stages II and III in the AJCC, and crossovers between stages I and II, and stages III and IV in the Japanese classification. The HR for OS demonstrated less statistical differences in the neoadjuvant group.

Conclusion: The AJCC 8th edition and Japanese classification 12th edition predicted survival well for patients received the upfront surgery, whereas both showed crossovers of survival curves for patients undergoing neoadjuvant therapy. More accurate staging systems for patients with ESCC who received neoadjuvant therapy and surgery are needed.

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来源期刊
Esophagus
Esophagus GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.90
自引率
8.30%
发文量
78
审稿时长
>12 weeks
期刊介绍: Esophagus, the official journal of the Japan Esophageal Society, introduces practitioners and researchers to significant studies in the fields of benign and malignant diseases of the esophagus. The journal welcomes original articles, review articles, and short articles including technical notes ( How I do it ), which will be peer-reviewed by the editorial board. Letters to the editor are also welcome. Special articles on esophageal diseases will be provided by the editorial board, and proceedings of symposia and workshops will be included in special issues for the Annual Congress of the Society.
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