接受手术和化疗的乳腺癌患者自我报告结果的亚组鉴定：一项横断面研究

IF 2.9 3区医学 Q1 NURSING

International Journal of Nursing Sciences Pub Date : 2025-01-01 DOI:10.1016/j.ijnss.2024.12.007

Feixia Ni , Tingting Cai , Tingting Zhou , Changrong Yuan

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引用次数: 0

摘要

目的探讨接受手术和化疗的乳腺癌患者自我报告预后及相关因素的亚组。方法于2021年1月至11月进行横断面研究。我们从中国上海的两家三级医院招募患者，采用住院期间的方便抽样。使用包括社会人口学和临床特征、患者报告结果测量信息系统概况-29 （promise -29）和promise -认知功能短表4a的问卷对患者进行评估。进行潜在类别分析，以检查自我报告结果的可能类别。采用多元logistic回归分析确定相关因素。对不同类别的症状进行方差分析（ANOVA）。结果共640例患者参与本研究。研究结果显示，在接受手术和化疗的乳腺癌患者中，自我报告的结果有三个亚组：低身体-社会认知功能、高身体-低认知功能和高身体-社会认知功能。多变量logistic回归分析显示，年龄（≥60岁）、绝经期、第三次化疗周期、单纯乳房切除术和乳房重建、病程3-12个月、III/IV期癌症、剧烈疼痛是功能衰退组的相关因素。此外，三组在抑郁和睡眠障碍方面存在显著差异。结论接受手术和化疗的乳腺癌患者可分为三个亚组。年龄、绝经期、化疗周期、手术类型、病程和分期、剧烈疼痛影响功能衰退组。因此，医疗保健专业人员应该制定量身定制的干预措施，以解决特定的功能康复和症状缓解需求。

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Identification of subgroups of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy: A cross-sectional study

Objectives

To identify the subgroups of self-reported outcomes and associated factors among breast cancer patients undergoing surgery and chemotherapy.

Methods

A cross-sectional study was conducted between January and November 2021. We recruited patients from two tertiary hospitals in Shanghai, China, using convenience sampling during their hospitalization. Patients were assessed using a questionnaire that included sociodemographic and clinical characteristics, the Patient Reported Outcomes Measurement Information System profile-29 (PROMIS-29), and the PROMIS-cognitive function short form 4a. Latent class analysis was performed to examine possible classes regarding self-reported outcomes. Multiple logistic regression analysis was used to determine the associated factors. Analysis of variance (ANOVA) was conducted for symptoms across the different classes.

Results

A total of 640 patients participated in this study. The findings revealed three subgroups in terms of self-reported outcomes among breast cancer patients undergoing surgery and chemotherapy: low physical-social-cognitive function, high physical-low cognitive function, and high physical-social-cognitive function. Multivariable logistic regression analysis showed that age (≥ 60 years old), menopause, the third chemotherapy cycle, undergoing simple mastectomy and breast reconstruction, duration of disease 3–12 months, stage III/IV cancer, and severe pain were associated factors of the functional decline groups. Besides, significant differences in depression and sleep disorders were observed among the three groups.

Conclusions

Breast cancer patients receiving surgery and chemotherapy can be divided into three subgroups. Aging, menopause, chemotherapy cycle, surgery type, duration and stage of disease, and severe pain affected the functional decline groups. Consequently, healthcare professionals should make tailored interventions to address the specific functional rehabilitation and symptom relief needs.

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来源期刊

International Journal of Nursing Sciences Nursing-Nursing (all)

CiteScore

6.10

自引率

2.60%

发文量

408

审稿时长

25 days

期刊介绍： This journal aims to promote excellence in nursing and health care through the dissemination of the latest, evidence-based, peer-reviewed clinical information and original research, providing an international platform for exchanging knowledge, research findings and nursing practice experience. This journal covers a wide range of nursing topics such as advanced nursing practice, bio-psychosocial issues related to health, cultural perspectives, lifestyle change as a component of health promotion, chronic disease, including end-of-life care, family care giving. IJNSS publishes four issues per year in Jan/Apr/Jul/Oct. IJNSS intended readership includes practicing nurses in all spheres and at all levels who are committed to advancing practice and professional development on the basis of new knowledge and evidence; managers and senior members of the nursing; nurse educators and nursing students etc. IJNSS seeks to enrich insight into clinical need and the implications for nursing intervention and models of service delivery. Contributions are welcomed from other health professions on issues that have a direct impact on nursing practice.