髌下脂肪垫损伤严重程度对急性前交叉韧带撕裂后髌股软骨退变的影响

IF 1.5 Q3 ORTHOPEDICS

Journal of orthopaedics Pub Date : 2025-01-20 DOI:10.1016/j.jor.2025.01.027

Griffin Harris , Nikhil Patel , Richard Wang , Anmol Patel , Selina Deiparine , Thomas M. Best , Jean Jose

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引用次数: 0

摘要

目的髌下脂肪垫（IFP）由于其结构和免疫调节特性在膝关节内环境平衡中起重要作用。本研究探讨急性前交叉韧带（ACL）撕裂时IFP损伤严重程度与髌股间室（PFC）软骨病未来发展的关系。方法纳入年龄在18-45岁，在2009年1月1日至2022年10月1日期间已知首次ACL撕裂的成人参与者。在受伤时伴有膝关节病变的患者被排除在研究之外。所有参与者都接受了ACL重建手术，并在术后两年内进行了随访mri。术前IFP水肿水平与术前和术后PFC水平一起被评估。我们通过随后的MRI扫描分析了初始IFP水肿与未来PFC进展之间的关系。结果本研究共纳入69名受试者。初始IFP损伤的严重程度与初始PFC软骨的存在无显著相关性（r = - 0.04, P = 0.61）。然而，初始IFP损伤的严重程度与PFC软骨的未来进展之间存在显著的正相关(r = 0.44, P <；0.001)。此外，当比较1级和2级IFP损伤时，PFC软骨的进展有显著差异（P = 0.001）。当比较2级和3级IFP损伤时，PFC软骨发育无显著差异（P = 0.72）。我们的研究强调了IFP在维持软骨稳态中的潜在作用，建立了IFP损伤的严重程度与ACL损伤后PFC的后续发展之间的联系。

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Impact of infrapatellar fat pad injury severity on subsequent patellofemoral cartilage degeneration following acute ACL tear

Objective

The infrapatellar fat pad (IFP) is important in the homeostasis of the knee joint due to its structural and immune-modulating properties. This study investigates the relationship between IFP injury severity during acute Anterior Cruciate Ligament (ACL) tears, and the future development of Patellofemoral Compartment (PFC) chondrosis.

Methods

Adult participants aged 18–45 years old who were known to have first-time ACL tears between 01/01/2009 and 10/1/2022 were included. Patients with concomitant knee pathologies at the time of injury were excluded from the study. All participants received ACL reconstruction surgery and had follow-up MRIs conducted within two years postoperatively. Preoperative IFP edema levels were assessed alongside both pre-and postoperative PFC. We analyzed the relationship between the initial IFP edema and future PFC progression on subsequent MRI scans.

Results

A total of 69 participants were included in this study. No significant correlation was found between the severity of initial IFP injury and the initial presence of PFC chondrosis (r = −0.04, P = 0.61). However, a significant positive correlation was observed between the severity of initial IFP injury and the future progression of PFC chondrosis (r = 0.44, P < 0.001). Additionally, a significant difference in the progression of PFC chondrosis was noted when comparing grade 1 to grade 2 IFP injuries (P = 0.001). No significant difference in PFC chondrosis development was identified when comparing grade 2 to grade 3 IFP injuries (P = 0.72).

Conclusion

Our study underscores the potential role of the IFP in preserving cartilage homeostasis by establishing a link between the severity of IFP injury and the subsequent development of PFC following ACL injury.

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.