线粒体中的DNA修复途径

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2025-02-01 DOI:10.1016/j.dnarep.2025.103814

Dillon E. King, William C. Copeland

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引用次数: 0

摘要

线粒体含有自己的小的，环状的基因组，存在于高拷贝数。线粒体基因组（mtDNA）编码电子传递链的基本亚基。线粒体基因组的突变与多种线粒体疾病有关，mtDNA的维持和复制对细胞健康至关重要。尽管维持线粒体DNA基因组完整性很重要，但线粒体中存在的DNA修复途径比细胞核中少。然而，线粒体有许多途径可以去除和降解DNA损伤，从而防止突变的积累。在这里，我们简要回顾了线粒体中存在的DNA修复途径，mtDNA突变的来源，并讨论了mtDNA突变在癌症进展中可能发挥的被动作用。

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DNA repair pathways in the mitochondria

Mitochondria contain their own small, circular genome that is present in high copy number. The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain. Mutations in the mitochondrial genome are associated with a wide range of mitochondrial diseases and the maintenance and replication of mtDNA is crucial to cellular health. Despite the importance of maintaining mtDNA genomic integrity, fewer DNA repair pathways exist in the mitochondria than in the nucleus. However, mitochondria have numerous pathways that allow for the removal and degradation of DNA damage that may prevent accumulation of mutations. Here, we briefly review the DNA repair pathways present in the mitochondria, sources of mtDNA mutations, and discuss the passive role that mtDNA mutagenesis may play in cancer progression.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.