Wenzhen Li , Hongyan Lin , Lvxin Peng , Qianhu Jiang , Yushu Gou , Lu Xie , Jian Huang
{"title":"AbNumPro：一个全面的离线工具包，用于抗体编号和抗原结合区预测","authors":"Wenzhen Li , Hongyan Lin , Lvxin Peng , Qianhu Jiang , Yushu Gou , Lu Xie , Jian Huang","doi":"10.1016/j.simpa.2024.100738","DOIUrl":null,"url":null,"abstract":"<div><div>Identifying complementary-determining regions (CDRs) and antigen-binding regions (ABRs) requires accurate antibody numbering, which is essential for therapeutic antibody development. AbNumPro is a comprehensive offline toolkit developed for antibody numbering and ABRs prediction, addressing the limitations of existing tools, which often lack comprehensiveness and rely solely on online services. By integrating five established numbering schemes—Kabat, Chothia, IMGT, Aho, and Martin—AbNumPro provides precise delineation of CDRs and ABRs, offering both compatibility with diverse research applications and the assurance of data security.</div></div>","PeriodicalId":29771,"journal":{"name":"Software Impacts","volume":"23 ","pages":"Article 100738"},"PeriodicalIF":1.3000,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"AbNumPro: A comprehensive offline toolkit for antibody numbering and antigen-binding region prediction\",\"authors\":\"Wenzhen Li , Hongyan Lin , Lvxin Peng , Qianhu Jiang , Yushu Gou , Lu Xie , Jian Huang\",\"doi\":\"10.1016/j.simpa.2024.100738\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Identifying complementary-determining regions (CDRs) and antigen-binding regions (ABRs) requires accurate antibody numbering, which is essential for therapeutic antibody development. AbNumPro is a comprehensive offline toolkit developed for antibody numbering and ABRs prediction, addressing the limitations of existing tools, which often lack comprehensiveness and rely solely on online services. By integrating five established numbering schemes—Kabat, Chothia, IMGT, Aho, and Martin—AbNumPro provides precise delineation of CDRs and ABRs, offering both compatibility with diverse research applications and the assurance of data security.</div></div>\",\"PeriodicalId\":29771,\"journal\":{\"name\":\"Software Impacts\",\"volume\":\"23 \",\"pages\":\"Article 100738\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-12-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Software Impacts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266596382400126X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"COMPUTER SCIENCE, SOFTWARE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Software Impacts","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266596382400126X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"COMPUTER SCIENCE, SOFTWARE ENGINEERING","Score":null,"Total":0}
AbNumPro: A comprehensive offline toolkit for antibody numbering and antigen-binding region prediction
Identifying complementary-determining regions (CDRs) and antigen-binding regions (ABRs) requires accurate antibody numbering, which is essential for therapeutic antibody development. AbNumPro is a comprehensive offline toolkit developed for antibody numbering and ABRs prediction, addressing the limitations of existing tools, which often lack comprehensiveness and rely solely on online services. By integrating five established numbering schemes—Kabat, Chothia, IMGT, Aho, and Martin—AbNumPro provides precise delineation of CDRs and ABRs, offering both compatibility with diverse research applications and the assurance of data security.
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